The time to turn negative for HPV53 positivity varies from person to person and is determined by the patient’s specific condition and treatment, which may be as fast as 3 months but may take up to 1 year for most patients. HPV53 positive means that the cervix is already infected with HPV virus. If the cervical TCT test is not abnormal and there are no obvious symptoms such as contact bleeding, drug treatment is feasible. If the patient is persistently infected and has cervical lesions on cervical TCT or colposcopy, cervical physical therapy or cervical conization is required. Since HPV infection is self-limiting, the virus can be cleared by the body automatically in most cases, resulting in a natural transformation, which can take as fast as about 3 months or as slow as 1-2 years to recover. In addition, HPV53 positive patients need to pay attention to rest, avoid staying up late, and maintain a regular life; at the same time, appropriate exercise, eat high-protein food, etc., to improve the body’s immunity, which is very helpful for the conversion of viral infection.