However, due to various restrictions and misunderstandings, antiviral therapy is almost equivalent to the conversion of viral indicators, as if the treatment of hepatitis B is for the negative conversion of viral indicators, and as long as the virus is negative, everything will be fine, but in fact, antiviral therapy is not simply the conversion treatment, and not every patient with hepatitis B is suitable for antiviral therapy. In fact, antiviral therapy is not a simple treatment, and not every patient is suitable for antiviral therapy, only strict control of the indications is needed to obtain limited efficacy; various drugs and programs are immature and in the experimental stage, users should establish a file and observe closely; the negative transformation of viral indicators may not be a good thing, we should pay close attention to the negative transformation caused by viral mutation; patients should not rush to try all kinds of treatment to avoid spending a lot of money, when they do not have the conditions of antiviral therapy, they can live and study normally and learn to live with the virus “Peaceful coexistence”. The purpose of antiviral treatment is to inhibit the replication of the virus and to eliminate the hepatitis B virus from the tissues and organs. 2. to improve liver function. 3. to reduce liver tissue lesions. 4. to improve quality of life. 5. to reduce and prevent the occurrence of cirrhosis and liver cancer. Reduce and prevent the occurrence of cirrhosis and hepatocellular carcinoma. Among them, in patients who meet the indications for treatment, it is only when the DNA turns negative, the E antigen turns negative and the E antibody turns positive through antiviral treatment that the virus is suppressed by the drug, while the surface antigen turns negative is very difficult. Secondly, it is currently possible to achieve a temporary negative of individual viral indicators, but it is not yet possible to achieve a negative of all viral indicators and a long lasting negative. So far, no matter how much money is spent and how many kinds of Chinese and Western drugs are used, it is difficult and unrealistic to make all hepatitis B viruses disappear completely from liver tissue or blood. If it is not used in accordance with its indications, nothing good will come out of it. The actual level of treatment at present is: if the drugs are used properly and the target of treatment is chosen appropriately, the hepatitis B virus can be negative for e antigen or/and hepatitis B virus DNA, but negative for hepatitis B virus surface antigen cannot be achieved yet. This is a more realistic goal for the treatment of hepatitis B. Third, although there are several more recognized drugs that have a certain effect on the conversion, but the indications are narrow, only a few patients meet their indications, only with a strict number into the seat, choose a good indication, it is possible to obtain effective treatment, regardless of the three, everyone to use antiviral drugs, that is, a waste of money, but also delay the disease. In the past decade, China has introduced and copied from abroad more than ten kinds of chemical drugs and biological agents, many of which have been proven to be ineffective or toxic side effects, is now rarely used, European and American countries have stopped for the treatment of hepatitis B, such as heparin, acyclic guanosine, adenosine, phosphonic acid, etc., a considerable number of patients, who have received these drugs, now look back and reflect, these treatments actually In retrospect, these treatments were actually experimental, and the patients’ treatment experience was actually money spent on tuition, in exchange for experience and lessons learned. The experience and lessons learned sum up the timing and conditions of antiviral therapy: patients with positive hepatitis B virus replication indicators, transaminases more than 2-5 times the upper limit of normal values, virus carriers and advanced cirrhosis are not suitable for antiviral therapy, such an initial qualification, the vast majority of hepatitis B patients have been excluded from antiviral therapy, if specific to a particular antiviral drugs, there are further qualifications, such as interferon The indications are strictly defined as follows: chronic hepatitis B “major triple-positive”, hepatitis B virus DNA positive, transaminase elevated 2 to 5 times suitable for interferon. The use of interferon is not suitable for patients with decompensated cirrhosis, those with high jaundice, those with normal liver function, and those with vertical transmission from mother to child, so that only a very small number of people meet its indications. From the actual situation of interferon use at present, a considerable number of cases simply do not meet the above-mentioned conditions of use, which are hard and brutal, and the efficacy is naturally poor. Even if the best recognized drugs are chosen and the indications are strictly mastered, the efficacy obtained is limited, the short-term effect is obvious, but the long-term efficacy is not ideal. Fourth, the ideal goal of antiviral therapy is to turn all the viral indicators negative, but at present, only a few indicators can be turned negative, and the actual meaning of these viral indicators negative is very complex, not all the viral indicators turn negative is good. Viral indicators in the blood are not static, their levels change every day, and their manifestations are sometimes changing; virus mutations can cause a negative change, and immune changes in the body can also cause a natural negative change in the virus. Stability of viral indicators is temporary, change is eternal. It is not an easy task to distinguish whether the change is caused by drug therapy or by natural changes in viral indicators, quantitative or qualitative. If the change in the number of hepatitis B viral indicators is observed regularly, it must be different every time, and it is difficult to confirm whether this change is caused by therapy or by natural changes; if If the indicator does turn negative, it is also difficult to determine whether this negative change is the result of medication or the result of the body’s autoimmunity. The key issue is that, in some cases, a negative change in viral indicators is not a good thing, because the hepatitis B virus can mutate in various forms when it is under drug pressure for a long time. The most common is the mutation of the pre-C and C regions of the hepatitis B virus, which can appear as “major triple-positive” to “minor triple-positive”, but this is not a good thing, the virus mutation is often the virus to escape from the fight, adapt to the role of drugs, disguise, change the form, more covert biological effects, the mutated virus may be more destructive and The body’s immune function is unable to identify and destroy the mutated strain of the virus, and the virus rushes up bad things even more recklessly. At present, it is found that most patients with hepatitis B cirrhosis have a serum virus status of “small triplet” rather than “large triplet”. That is to say, patients waiting for the viral indicators to turn negative is not always a good thing. Fifth, there are many drugs and the cost of treatment is increasing, so it is indeed a waste to invest a lot of medical funds in the pursuit of illusory or specious treatment goals. All medical professionals clearly know and acknowledge that there is no ideal, effective hepatitis B drugs available, the more so, the more various drugs and therapies with trial and error, this expert recommended the use of this program, that expert recommended the use of that drug, Shanghai has a set of Shanghai, Beijing has a set of Beijing, each for their own, currently there are advocates of combination therapy, there are advocates of sequential therapy There are those who advocate interferon combined with lamivudine, and those who advocate interferon combined with Ritalin, and those who advocate western medicine interferon, lamivudine, and Ritalin combined with Chinese medicine preparation bitter ginseng, etc. For the treatment protocols in the trial stage, we should be cautious, and it is better not to promote things that are specious without clinical validation in large samples. This is definitely not the case, before there is a method to eliminate the virus, you should learn to “live in peace” with the virus. The number and replication of hepatitis B virus is not a direct factor in aggravating the disease, that is, the number of hepatitis B virus and the severity of the disease is not proportional to the relationship, many patients with long-term hepatitis B “major triplet”, but the body There are many patients who have been in good health for a long time and have lived a long life, and there are many people who have naturally turned negative and healed themselves. If the immune function is paralyzed or tolerated, the body’s immune function lacks recognition of the virus, and even if the virus exists, it may not necessarily develop, at which point the body and the hepatitis B virus “coexist peacefully”, and it may not be impossible to survive with the virus. In the absence of a complete attack on the hepatitis B virus, it is much better to take stable and safe measures than to be aggressive and mess up the immune function and try various drugs indiscriminately. A number of domestic and foreign scholars are currently proposing immune tolerance therapies along these lines. Oral administration of viral structural proteins can induce immune tolerance in a simple way for the treatment of hepatitis B. Inducing a state of tolerance to the virus helps to reduce lesions and delay the onset of complications. Whether specific measures are feasible in our country is yet to be decided, but this move is not a way out. Seven, long-term endless conversion treatment, so that patients are physically and mentally exhausted, laborious, and often returned to the disappointment and frustration. To say that the biggest victim of the endless attempts at various treatments is definitely the hepatitis B patients, who initially reported a strong desire and confidence in treatment, actively seeking medical advice, going around to see a doctor, to the end of the disease is still recurring, the virus indicators a little unchanged or change back and forth, money exhausted, when running out of ammunition, bringing only pain and disappointment. In order to prevent the majority of patients from repeating the mistakes of their predecessors in terms of unhelpful treatment and unnecessary expenses, medical workers have the obligation to conscientiously warn hepatitis B patients: they must use antiviral drugs carefully, not blindly, and only under the condition that they fully comply with the indications for antiviral treatment and have sufficient financial strength can they try to use them, and the whole process of using them must always be carried out under the guidance of regular hospitals and doctors, with regular Follow-up visits, the establishment of files. Many medical practitioners of a charlatan nature or bad people who are eager to make money take the opportunity to make waves, they seize the urgent psychology of the patient’s request to turn the negative, making all kinds of advertisements, boasting how effective the effect of turning the negative, applying some “scientific terms”, the preparation of amazing scientific “myths “The State Administration for Industry and Commerce and the Ministry of Health have solemnly declared that the State Administration for Industry and Commerce and the Ministry of Health are committed to the implementation of the hepatitis B treatment. The State Administration for Industry and Commerce and the Ministry of Health have solemnly announced the suspension of hepatitis B advertisements in various media or occasions, but for a long time, the hepatitis B advertisements appearing in various media have almost become a public nuisance, the number of advertisements, the wide coverage area, the variety of forms, the vivid language, the great seductive power, the misappropriation and fabrication of scientific terminology, can be described as one of the best, almost all of the hepatitis B advertisements are based on the propaganda “The purpose is to grasp the psychology of patients who eagerly hope for the negative transformation of hepatitis B virus. The desire of those undesirable elements gully, rely on cheating hepatitis B patients and make a fortune of individuals and units are numerous.