After discontinuing hydroxychloroquine for 5 days, the discontinuation response is inconsistent from patient to patient because of individual differences in disease and responsiveness to hydroxychloroquine. Hydroxychloroquine is an immunosuppressant, which is used clinically for the treatment of various rheumatic immune diseases, but the effect of this drug is slow, and it usually takes 3-4 months to gradually show the therapeutic effect. If hydroxychloroquine is discontinued for 5 days, the response to hydroxychloroquine discontinuation varies from patient to patient due to different diseases and reactivity to hydroxychloroquine. Some patients may not show any discomfort, but others may show a relapse of the original disease and an increase in signs and symptoms. Therefore, patients are not advised to reduce or discontinue hydroxychloroquine on their own. In addition, patients should regularly follow up with their doctors for guidance and assistance during the use of hydroxychloroquine, and adjust the dosage of hydroxychloroquine under the guidance of doctors according to the changes in their conditions, rather than reducing and stopping the drug on their own.