When acute infectious splenomegaly progresses to megasplenism, it is often severely enlarged and soft with tenderness. After control of the infection, the spleen may return to a subnormal size. Splenomegaly due to chronic infection is often markedly increased in texture due to fibrous tissue proliferation. The spleen does not return to normal size after infection control. Megasplenism can be diagnosed by palpation: Rheumatism, true erythrocytosis, and primary thrombocythemia may also present with mild splenomegaly. Chronic hemolytic anemia, cirrhosis of the liver, chronic lymphocytic leukemia, malignant lymphoma, and acute leukemia are associated with moderate splenomegaly. High degree of splenomegaly (megasplenism), mainly seen in chronic granulocytic leukemia, myelofibrosis, schistosomal hepatic fibrosis, and so on. Infections that directly invade the spleen, such as splenic abscess, splenic tuberculosis, etc., are often accompanied by splenic periarthritis, which may be characterized by friction with tenderness on palpation and friction sounds on auscultation. If the blood supply of the giant spleen garden is insufficient and splenic infarction occurs, there is also obvious pressure pain, friction sensation and friction sound. Chronic congestive splenomegaly, regular shape, smooth surface}Splenic tuberculosis can be detected nodules; lymphoma, splenic cysts and splenic tumors can cause the surface of the spleen is not smooth and deformation.