Splenectomy in severe hypersplenism with coagulation dysfunction is one of the daily tasks of pancreatic and splenic surgery. The routine countermeasures in our department are: 1. Continuous shock treatment with relevant drugs for three days before surgery to improve platelet count at the time of surgery; 2. Intraoperative spare platelets and cold precipitation applied after splenic artery ligation; 3. Intraoperative use of blood cell recovery device to strive not to lose a single red blood cell; 4. Intraoperative routine use of ultrasonic knife operation to reduce bleeding and spare argon knife to cope with traumatic bleeding; 5. Intraoperative preparation of bioprotein gel, Hemostatic powder, hemostatic gauze, etc. to enhance the hemostatic effect.