Parenchymal splenic ablation therapy is the destruction of splenic tissue by various ablative methods. It is a minimally invasive technique and a field of modern minimally invasive surgery. The rapid emergence of interventional minimally invasive techniques to achieve the desired therapeutic effect with minimal trauma and pain, a dream that has been pursued for centuries, is now gradually becoming a reality. Cirrhosis is a common disease and one of the major causes of death in China, clinically characterized by impaired liver function and portal hypertension. Due to the obstruction of blood return to the spleen caused by the elevated portal pressure, the spleen is enlarged by blood stasis, and then hypersplenism occurs, which manifests itself as hypersplenism syndrome with enlargement of the spleen, reduction of one or several blood cell components in the blood, and corresponding increase of bone marrow hematopoietic cells. The treatment of hypersplenism has always been one of the hot topics in the medical field, and the traditional method is to use splenectomy or partial splenectomy to alleviate the symptoms of hypersplenism. However, this method is difficult to accept for many patients (especially those with hepatic cirrhosis and hypersplenism) due to low blood cells, hypoproteinemia and ascites, etc. At the same time, the spleen as an immune organ increases the risk of serious infections after resection. In the past 30 years, some scholars at home and abroad have carried out research on splenic ablation in animal experiments and clinics, which is called internal splenectomy, and has now become a widely used method of treating hypersplenism in clinics. Our department has carried out this treatment for more than 50 cases, accumulated rich experience, the effect is remarkable, the project has been awarded the 2012 “fill the gaps in medical science in Tianjin Award”.