Therefore, when the tumor growing in the liver is small, usually less than 5cm, it does not feel pain and has no symptoms, therefore, patients will not take the initiative to check it, so early stage liver cancer is not easy to be detected except for ultrasound physical examination. Most of the symptomatic hepatocellular carcinoma is in the middle and late stages, and the treatment of patients at this time is very difficult, plus about 80% of hepatocellular carcinoma patients have liver cirrhosis, liver insufficiency, ascites and poor coagulation mechanism, which greatly limit the surgical resection. Therefore, the main goal of treatment for middle and late stage hepatocellular carcinoma is to improve patients’ quality of life, prolong survival time and reduce pain, which is also the disease we have to try to overcome most. Appropriate non-surgical resective local minimally invasive therapies are preferred to kill a large number of cancer cells as the central part of comprehensive treatment. Minimally invasive interventions: 1. hepatic artery chemoembolization (TACE): percutaneous femoral artery puncture hepatic artery embolization is the treatment of choice for patients with liver cancer who cannot be treated surgically. Its principle is based on the fact that 25% of blood supply to normal liver tissue comes from hepatic artery and 75% from portal vein, while almost all blood supply to liver cancer nodules comes from hepatic artery. If the hepatic artery branch, which provides nutrition to the tumor, is cannulated and embolized, it can not only block the blood supply to the cancerous tissues and limit the growth of the tumor, but also cause necrosis and shrinkage of the cancerous tissues without causing liver failure. However, hepatocellular carcinoma must still have portal vein blood supply and hepatic exogenous blood supply, such as the blood vessels wrapped by the greater omentum and the blood vessels on the diaphragm, which are beyond the reach of interventional embolization. 2.Alcohol injection method: PEI was developed in 1982, mainly for the treatment of small hepatocellular carcinoma. The main mechanism of action is to use anhydrous alcohol to rapidly dehydrate and fix the tumor tissues, causing ischemic necrosis. This method is easy to operate, less painful, less complications and low cost. 3.Percutaneous microwave coagulation therapy (PMCT): It is not only applicable to small liver cancer, but also can achieve the effect of eliminating tumor by using the combination of multi-level, multi-needle, multi-point and multi-power time for middle and late stage liver cancer, and the stimulation of coagulated necrotic tumor tissue can improve the immunity of the body and modulate the residual or still cancerous tissue cells, which opens up a new way for liver cancer treatment. 4. Permanent inter-tissue implantation of radioactive particles is a new method of liver cancer treatment, which is imaginatively called “particle knife” by some people in the medical field. It is a minimally invasive method, such as ultrasonic intervention, to directly implant several encapsulated radioisotopes with certain specifications and activity into liver cancer tissues through source applicator or source catheter, and arrange the radioactive sources according to certain rules according to the size and shape of the tumor to irradiate the tumor tissues at a close distance and high dose to achieve the purpose of treating the disease. 5.Biological therapy, tumor biotherapy is a new method of applying modern biotechnology and its products for tumor prevention and treatment. With the in-depth research on the molecular mechanism of tumor development and the development of biotechnology, biological therapy has become a new mode in the comprehensive treatment of tumor, which is getting more and more attention. At present, the drugs that can be used alone or combined with other methods of biological therapy are IL-2, TNF, IFN and so on. At the same time, immunotherapy and herbal drug therapy are also adjuvant means of liver cancer treatment. Interventional ultrasonic microwave local ablation of liver tumor is the main treatment, combined with local sclerotherapy injection, hepatic portal vein local chemotherapy, peritumor immune enhancer injection and other comprehensive treatment, its practicality, safety and effectiveness, minimally invasive, low cost and other advantages have gradually been clinically recognized and promoted, becoming an important means of comprehensive minimally invasive treatment. Microwave ablation focuses on the coagulation of trophoblastic vessels, and the ablation range exceeds 0.5-1.0 cm of tumor perimeter. For tumors born in difficult sites beside the gallbladder and intestinal tract, the treatment can be combined with sclerotherapy injection to prevent thermal damage to the gallbladder and intestinal tract, resulting in serious complications. For those who have difficulty in exposing the lesion, saline injection into the artificial chest or abdominal cavity is used to enhance the display of the puncture path and clear visual field. For tumors that are too large, with extremely rich blood supply and more than four trophoblastic vessels, it is estimated that local microwave ablation is difficult to eliminate completely, and transhepatic artery embolization is given first to shrink the tumor, and then local microwave ablation is used to completely inactivate it. After ablation, there must be residual cancer cells in the coagulation area, so sclerosing agents, chemotherapy drugs and radioactive particles can be injected to consolidate the therapeutic effect, and immune enhancers can be injected around the tumor to modulate the cancer cells, and the combined application of these methods can obviously enhance the therapeutic effect, reduce complications and obtain good results.