Liver fibrosis is a pathological process of chronic liver disease. Chronic inflammation and necrosis of hepatocytes due to various causes can cause proliferation of fibrous connective tissue in the liver. The deposition of large amounts of fibrous connective tissue in the liver is called hepatic fibrosis, and if accompanied by the destruction of liver lobules is called cirrhosis, hepatic fibrosis is a chronic and progressive process. Generally speaking, liver fibrosis is present when there is chronic hepatitis, but the degree of severity varies. Currently, the most reliable method to diagnose liver fibrosis is liver histological biopsy, although there are several liver fibrosis serum marker tests in clinical use, but their specificity needs to be improved. Recent studies on the mechanism of liver fibrosis formation have confirmed that the cellular and extracellular matrix components of the liver fibrosis process are dynamically changing, rather than a haphazard static accumulation, suggesting that recovery of liver fibrosis is possible. With the advent of effective antiviral therapy, the etiology of chronic liver injury caused by hepatitis B and C viruses can be effectively treated, thus providing a guarantee for the treatment of liver fibrosis at the source, but pure etiological treatment is far from sufficient, so anti-liver fibrosis treatment also needs to start from a pathological perspective. Current research on the mechanism and efficacy of Chinese medicine against liver fibrosis shows that Chinese medicine has obvious advantages in anti-liver fibrosis treatment and is also a more commonly used anti-liver fibrosis treatment in clinical practice. The process of liver fibrosis is long and the treatment of hepatitis B and C viruses cannot be completely removed, so the treatment of liver fibrosis also requires long-term, even lifelong treatment. In conclusion, more and more data suggest that liver fibrosis can be reversed. And as the research on liver fibrosis continues, human beings will eventually master the mystery of liver fibrosis formation and degradation, and create more new methods and drugs to treat liver fibrosis.