First of all, explain what is hepatitis B. The real meaning of the transfer of the negative or more complete transfer of the negative is the transfer of the surface antigen, once the surface antigen is transferred to the negative, it can be said that hepatitis B has completely recovered. However, the possibility of this kind of conversion is very small, some have a relationship with the treatment, and some have achieved this kind of conversion without medication. I have had many such lucky people in the course of treatment, but the chances are small compared to all hepatitis B patients. There are no particularly effective drugs that can achieve this kind of conversion. Myth: Some commercial propaganda in our society says that a few injections or cellular therapy can make patients turn negative quickly, but these are not scientific or credible. It is because it is difficult to achieve this kind of transformation, so the medical transformation is located in the E antigen transformation and DNA transformation, through this transformation treatment can stabilize the disease, and this transformation can be achieved through the appropriate treatment. The drugs are divided into the interferon class, including ordinary interferon and pegylated interferon (long-acting interferon), and the nucleoside class, including lamivudine (hesperidin), adefovir, telbivudine and entecavir, etc. Tenofovir has not yet entered our country. The so-called transmutation therapy is through the rational treatment of these drugs, so that patients can achieve E antigen transmutation (with E antibody production is better) and DNA transmutation, in this treatment process, a few patients are lucky to obtain the surface antigen transmutation. For the selection of the treatment plan, the following factors should be considered: 1. the age of the patient: generally older patients (35-40 years old and above) need treatment more than younger patients, and young people are more suitable for interferon therapy; 2. gender: male patients are more likely to be combined with alcohol consumption, which makes the disease more aggravated and requires more treatment. Interferon therapy is more effective for women than men; 3. family history, patients with cirrhosis or liver cancer in the family should take active measures to prevent cirrhosis and liver cancer; 4. ALT (transaminase) levels: higher transaminase levels are more effective, especially for interferon therapy; 5. DNA levels, the higher the DAN level, the more difficult it is to treat, and the greater the likelihood of future viral mutations. The higher the level of DAN, the more difficult it is to treat, and the greater the likelihood of subsequent viral mutation, it is advisable to choose drugs with strong antiviral ability or consider combination therapy for high DNA levels; 6. 8 specific situation: also take into account the patient’s economic situation, marriage and childbirth, work and study; 9, the characteristics of various drugs: each drug has its different characteristics, according to the patient’s condition and the specific situation of the comprehensive analysis; 10, drug resistance: before the treatment should be considered after the possible drug resistance problems, to prevent in advance and be prepared for drug resistance treatment; 11, safety 11. Safety: choose a treatment plan that is as safe as possible. A reasonable treatment plan requires active communication between the doctor and the patient, and can only be decided after integrating various factors. It is unrealistic and unscientific to hope that one or two injections will turn the disease around.