The main symptoms of advanced cholangiocarcinoma include jaundice caused by the cholangiocarcinoma itself, as well as some specific symptoms that occur after metastasis to certain organs. In advanced bile duct cancer, the bile ducts are blocked and bile cannot be discharged to the intestine, which causes more obvious yellow sclera and skin staining. Due to the large amount of bilirubin deposits in the skin, itchy skin discomfort may also occur. Since there is no fecal bilinogen from the bile in the stool, the stool will appear white, and the urine will appear golden yellow due to a high concentration of urobilinogen in the urine. Since bile cannot enter the intestine and food is not well digested, intestinal symptoms such as bloating, abdominal pain, and nausea and vomiting occur. This disease itself is a malignant disease, so problems such as extreme malnutrition can occur. The most likely site for bile duct cancer to metastasize is the liver, and abdominal pain may occur after metastasis. If the biliary tract is blocked for a long time, liver failure may occur, which is characterized by high bilirubin and normal transaminases, i.e. “enzyme-biliary separation”. For example, metastasis to the lung may cause coughing and hemoptysis, but this is a rare case. Generally speaking, bile duct cancer is insidious in its onset, and it is only discovered when the jaundice is severe, and after it is discovered, many of them are in advanced stage, which makes the treatment very difficult and the treatment effect is not good. Therefore, it is important to pay attention to regular medical checkups to detect abnormalities in time.