Depression is not a terminal illness in clinical practice, and after systematic and standardized treatment, 60% to 80% of depressed patients can be clinically cured, and the cure rate of depression is still relatively high. The main treatment means of depression in the clinic include medication, psychotherapy and physical therapy. Medication is mainly the standard application of 5-hydroxytryptamine reuptake inhibitors and other related antidepressant drugs, through standardized and systematic treatment, the patient’s body 5-hydroxytryptamine levels will be improved accordingly, and then improve the patient’s mood, thinking and other depressive symptoms. For patients with mild depression, cognitive-behavioral therapy can effectively improve the symptoms. Physical therapy is widely used in clinical settings, such as transcranial magnetic stimulation and electroconvulsive therapy.