In 2050, the global population over 60 years of age will be larger than the population under 15 years of age, and the impact of an aging society or population aging on men’s health has become a common challenge in the global village. Late-onset hypogonadism (LOH), also known as partial androgen deficiency and male menopause syndrome, is of great concern because of its high prevalence, its impact on multiple target organs or systems in men, and its severe reduction in quality of life, especially in middle-aged and elderly men. The establishment of a clinical intervention system for the prevention and treatment of LOH is urgent, and it is urgent to explore a diagnostic scale and diagnostic targets for the genetic characteristics of male reproduction in China, and to establish a social support system, comprehensive intervention measures and prevention system based on community health care that is compatible with a harmonious society. Challenge 1: High prevalence of LOH accompanied by the process of male aging Challenge 2: Multiple target organs or systems involved in LOH Challenge 3: The pathogenesis of LOH needs to be explored Intervention 1: Exploring the diagnostic scale of LOH suitable for China’s national conditions Intervention 2: Exploring the diagnostic target system of LOH with China’s male reproductive genetic characteristics Intervention 3: Establishing a social support system of LOH compatible with a harmonious society Intervention 4: Establishing a comprehensive system of LOH including androgen supplementation Intervention 5: Establish a LOH prevention system including environment, diet and exercise. Male aging is an irreversible process in human history, but aging can be delayed and postponed, and ageing-related diseases can be prevented (prevent the preventable and delay the inevitable). inevitable). Shanghai medical workers have the responsibility, obligation and ability to work together with all citizens under the leadership of the government to establish a clinical intervention system that is compatible with a harmonious society and serve to build a healthy and vibrant aging society.