The most common clinical treatment for syphilis, which is for early syphilis, is usually long-acting penicillin as the drug of choice, which is administered intramuscularly once a week, three times as a course of treatment. If allergic to long-acting penicillin, ceftriaxone, doxycycline, azithromycin, minocycline, and tetracycline can be used. The titer is usually controlled at about 1:4 and can be stopped for observation. If the titer can always be maintained at about 1:4, there is no need to continue the medication. In principle, syphilis needs to be observed for more than three years before you can judge whether there is a possibility of cure. The titer of syphilis should be reviewed once every three months in the first year, once every six months in the second year, and once at the end of the year in the third year. During the last review, it is best to do a cerebrospinal fluid aspiration to rule out neurosyphilis.