Causes of true precocious puberty are mainly due to organic lesions of the central nervous system, idiopathic and primary hypothyroidism: (1) Acquired: such as brain abscess, cranial radiation therapy, cranial inflammation, cranial trauma and surgery, etc. (2) Congenital: such as arachnoid cyst, hydrocephalus, hypothalamic malformation, septum-optic nerve dysplasia, cranial saddle cyst, etc. (2) Congenital: such as arachnoid cyst, hydrocephalus, hypothalamic malformation, septum-optic nerve dysplasia, cranial saddle cyst, etc.; (3) Brain tumor: such as adenoma secreting luteinizing hormone (LH), astrocytoma, glioma, etc. (2) Idiopathic precocious puberty: the cause is still unknown. Most of the patients in this category have sporadic onset, a few have family characteristics, and the common one is idiopathic central precocious puberty in girls. The overall incidence of precocious puberty in children is mostly seen in girls, and the ratio of male to female is about 1:4. Among them, central precocious puberty is still higher in girls than in boys, and the ratio of male to female is about 1:23. The most common cause of central precocious puberty in girls is idiopathic precocious puberty, which accounts for about 80%-90% of central precocious puberty in girls.
-The most common cause of central precocious puberty in girls is idiopathic precocious puberty, which accounts for about 80% of central precocious puberty in girls. 3, primary hypothyroidism: primary hypothyroidism is “cretinism” children, if the condition persists without thyroxine replacement therapy, it can cause true precocious puberty.