Leukocerebrosida syndrome is also known as ocular, oral and genital syndrome. It is a chronic progressive multisystemic damage disease of unknown cause based on the pathology of microvascular vasculitis. The disease is associated with autoimmune function and viruses Recurrent oral mucosal ulcers are the earliest symptom of the disease. Genital ulcers are also a symptom. The eyes are commonly affected by iridocyclitis, anterior chamber pus accumulation, conjunctivitis, keratitis, or retinal vasculitis, and can affect vision. Among them, eye symptoms are diverse and can manifest as blurred vision, vision loss, eye pain, photophobia and tearing, foreign body sensation and flying mosquitoes, which can lead to blindness in severe cases. If you lack a holistic understanding of the disease, you may describe each symptom separately to different doctors, often resulting in a situation of “treating the head when it hurts and treating the foot when it hurts”, losing the opportunity to receive the best treatment plan. Skin conditions such as impetigo, folliculitis, boils, cellulitis, ulcers, and erythema nodosum-like rash may occur. In addition, cardiovascular, gastrointestinal, and neurological lesions or systemic symptoms such as fever, dizziness, headache, malaise, and arthralgia can occur, and the disease can last for years to decades due to periodic remissions and relapses, such as involvement of the central nervous system, vital organs, and other macrovascular lesions are the main cause of death.