Leukocerebrosida syndrome is an autoimmune disease. The syndrome was originally described as a triad of recurrent oral ulcers, pubic ulcers, and uveitis. Later, it was recognized as a systemic disease. It can involve multiple systems and organs. Those who are typical or meet the diagnostic criteria can be called leukoplakia. However, many patients are atypical or do not yet meet the diagnostic criteria, especially in some diseases such as ulcerative colitis, granulomatous enteritis, and segmental ileitis. It can also cause a similar triad of manifestations, so collectively it is better to call it white stuffy syndrome. Clinical manifestations The main manifestations are oral ulcers, pubic ulcers and uveitis (triad), and there may be skin damage (quad), or it may invade other systemic organs.