Leukocerebral syndrome is a multisystemic disease characterized by recurrent oral, genital and ocular ulcers. The disease is most prevalent in young men and women in the Mediterranean, Middle and Far East, suggesting a connection to the ancient Silk Road. It is equally prevalent in men and women, and is usually more severe in men. The etiology and pathogenesis of the disease are unknown, with vasculitis being the main pathological injury, in addition to a tendency to form venous thrombosis. anti-human oral mucosal antibodies can be found in the serum of 50% of patients. In endemic regions, the disease is associated with the human autoantigen HLA-B5/51. Clinical manifestations: 1, recurrent oral aphthous ulcers, ulcers are usually painful, ulcers can be deep or shallow, with a central yellow necrotic base, can occur singly or in clusters, can be located in any part of the oral cavity, ulcers last 1 to 2 weeks, healing does not leave a scar. 2. Genital ulcers are less common, but they are more specific for the diagnosis of the disease and can cause scrotal atrophy without invading the glans and urethra. 3, Skin involvement includes folliculitis, erythema nodosum, acne-like rash, and any stirring or intradermal injection of saline (prick test) can trigger a nonspecific inflammatory skin reaction. 4. Ocular involvement scar formation, and bilateral allodynia are serious complications of the disease and can easily lead to blindness. Ocular manifestations usually manifest at the beginning of the disease, but can also appear within a few years of onset. In addition to uveitis, retinal vascular obstruction and optic neuropathy may also occur. 5. Arthritis, a non-teratogenic inflammation of the joints. 6.Superficial or deep vein thrombosis occurs in 1/4 patients. 7.Neurological involvement, mainly in the form of brain parenchymal injury. 8, Gastrointestinal manifestations in the form of intestinal mucosal ulcers. Laboratory tests: non-specific inflammatory indicators are abnormal, such as leukocytosis, elevated erythrocyte sedimentation rate, and elevated C-reactive protein. Anti-human oral mucosal antibodies may also be found. Prognosis and treatment: The severity of the disease usually decreases with time. The survival of the disease is normal except in patients with parenchymal involvement of the nervous system. Colchicine or interferon alpha are effective against the cutaneous mucosal symptoms of the disease. Uveitis and central nervous system involvement require systemic treatment with glucocorticoids or cyclosporine.