Ankylosing spondylitis has a family tendency to run in families, which means that the disease has a genetic predisposition. Will treatment and medication have an effect on fertility? These are often the concerns of patients and their families. Ankylosing spondylitis is a disease of many causes, and genetics is only one of them, not the only factor that affects the disease. In other words, if a patient has ankylosing spondylitis, the likelihood that his or her child will develop the disease is only 20 to 30 percent. Some patients with ankylosing spondylitis, even if they are HLA-B27 antigen positive, their children are not all positive, and even if their children are positive, they do not necessarily have the disease, because about 5% of normal people can be positive for HLA-B27 antigen. Therefore, there is no need to worry too much about heredity, you should have a normal child, later on the child can do long-term follow-up in rheumatologists, early prevention and control, do not worry too much. In terms of medication, the treatment of ankylosing spondylitis drugs such as sulfasalazine, methotrexate, and rheumatism have some effect on the gonads, but they are reversible. It has also been reported that methotrexate has the side effect of causing fetal malformation, but it mostly occurs after a larger dosage, and the total amount of the full course of treatment in the treatment of ankylosing spondylitis does not exceed 1000 mg at most. However, from the perspective of eugenics, the drug should be discontinued six months or more in advance when preparing for childbirth, which generally does not affect the quality of fertility. If you’re taking too much NSAIDs and analgesics for too long, they can inhibit prostaglandin synthesis, so they can have some adverse effects on sexual function, but they are reversible and can return to normal after adjustment or discontinuation. The actual fact is that you can find a lot of people who are not able to get a good deal on this. Therefore, after the disease, you should not just think every day whether the disease will develop, whether it will cause deformity, what to do in the future, such emotions are very detrimental to the recovery of the disease, should correctly arrange the time of life, study, treatment, exercise, and treat the disease with a good mood. Furthermore, depressed mood can also lead to the slowing down of the circulation of all organs in the body and the decrease of resistance, which can easily cause other diseases. Through the resolution of psychological barriers, the correct evaluation of their own disease, the patient’s attitude from negative to positive, the patient’s mood from pessimism to optimism, with the treatment on the passive to active, so that patients with ankylosing spondylitis have a healthy state of mind, with external treatment so that the pathology of the body also towards health.