TNM grading definition

T Grading

T grading scale

For papillary, follicular, hypofractionated, Hürthle cell, and undifferentiated thyroid carcinomas
undifferentiated cancers

TX

Primary tumor cannot be evaluated

T0

No evidence of tumor

T1

Tumor confined to the thyroid with a maximum diameter of ≤2cm

T1a

Tumor ≤1cm in maximum diameter

T1b

Tumor maximum diameter >1cm, ≤2cm

T2

Tumor maximal diameter >2cm, ≤4cm

T3

Tumor >4cm and confined to the thyroid, or largely invading the extra-thyroidal band

T3a

Tumor >4cm and confined to the thyroid gland

T3b

Large invasion of the extrathyroidal band muscles, regardless of tumor size (band muscles include: sternocleidomastoid, sternocleidomastoid, thyroglossus, scapulocleidomastoid)

T4

Largely invasive outside the extra-thyroidal band muscles

T4a

invasion of the larynx, trachea, esophagus, laryngeal denervation and subcutaneous soft tissues

T4b

invading the prevertebral fascia, or encapsulating the carotid artery and mediastinal vessels

For medullary thyroid carcinoma

TX

Primary tumor cannot be evaluated

T0

No evidence of tumor

T1

Tumor confined to the thyroid with a maximum diameter of ≤2cm

T1a

Tumor maximum diameter ≤1cm

T1b

Tumor maximum diameter >1cm, ≤2cm

T2

Tumor maximal diameter >2cm, ≤4cm

T3

Tumor >4cm and confined to the thyroid gland, or largely invading the outer thyroid band
muscle

T3a

Tumor >4 cm and confined to the thyroid gland

T3b

Large invasion of the extra-thyroidal band, regardless of tumor size

T4

locally advanced

T4a

Moderately progressive, tumor of any size, invading peripheral cervical organs and soft tissues outside the thyroid
Tumors of any size invading peripheral organs and soft tissues of the neck outside the thyroid, such as the larynx, trachea, esophagus, laryngeal denervation, and subcutaneous soft tissues

T4b

Severe progression, tumor of any size, invading the prevertebral fascia, or encapsulating the cervical arteries, mediastinal vessels
artery, mediastinal vessels

N grade

N grading criteria (for all thyroid cancers)

NX

Regional lymph node metastasis cannot be assessed

N0

No evidence of lymph node metastasis

N1

Regional lymph node metastasis

N1a

Metastases to regions VI and VII (including paratracheal, pre-tracheal, anterior laryngeal/Delphian
or upper mediastinum) lymph nodes, either unilaterally or bilaterally

N1b

Unilateral, bilateral, or contralateral lymph node metastases in the lateral cervical region (including regions I, II
III, IV, or V) or retropharyngeal lymph node metastases

M grade

M grading criteria (for all thyroid cancers)

M0

No distant metastases

M1

with distant metastases