Ankylosing spondylitis is a chronic and recurring rheumatic disease, so regular follow-up with a regular rheumatologist is a must for patients. The review program of course includes two aspects like other rheumatic diseases: evaluation of efficacy and monitoring of side effects, of which urinary routine is the most easily ignored and very important items. There are several reasons for this: 1. Urinary abnormalities can be a manifestation of this group of diseases: ankylosing spondylitis is not only a disease affecting the joints and spine, it is also a systemic disease, some patients will develop kidney damage, the most common type of pathology is IgA nephropathy, manifested as hematuria and/or proteinuria, or even renal insufficiency creatinine elevation, but of course there can be other types of pathology used, a variety of urinary The most common damage caused by the disease itself in advanced patients is amyloidosis, and checking the urinary routine can also provide some clues. 2, urinary abnormalities can be the cause of this group of diseases, in the case of strict pursuit of medical history, about 70% of the occurrence, exacerbation or recurrence of spondyloarthritis or ankylosing spondylitis are related to urinary or gastrointestinal tract infections, the detection of urinary sensation will be of great help in the treatment of the disease. There is also a type of spondyloarthritis for reactive arthritis and urinary tract infection is more closely related, although anti-infective treatment does not have definitive evidence to prevent the occurrence and development of the disease, but for a small number of patients is still meaningful. 3, urinary abnormalities is one of the most common side effects of drugs, such as non-steroidal anti-inflammatory drugs is currently the most effective class of therapeutic drugs, the side effects include kidney damage, this side effect generally has two types, one is hypersensitivity reactive, as soon as the exposure immediately, within 1-3 days of proteinuria, hematuria or tubular urine leukocytes urine, a cumulative if a long-term mass application of a drug More than 10 years, a kind of analgesic nephropathy can appear, with interstitial damage dominated by renal insufficiency, etc. Another drug most commonly used to treat this group of diseases is salazosulfapyridine, oral salazosulfapyridine if you can not ensure adequate water intake, can appear sulfa drug renal damage, of course, there will be hypersensitivity reactive renal damage in sensitive individuals, these are to be alert, although the incidence is very low, most patients are safe to apply, but must be vigilant, once the appearance of the treatment plan should be adjusted in a timely manner, and the test urine routine is an easy and economical means. Therefore, patients who receive drug therapy or are about to receive drug therapy would be well advised to have regular urine tests to detect renal damage and deal with it in time.