Hyperuricemia is the most important biochemical basis and the most direct cause of the development of gout. Gout specifically refers to acute characteristic arthritis and chronic gout stone disease, which can be complicated by renal lesions, and in severe cases, joint destruction and impaired renal function. Hyperuricemia is divided into the following three types according to blood uric acid level and uric acid excretion: 1. poor uric acid excretion type 2. excessive uric acid production type 3. mixed type After examination by a doctor and correction by creatinine clearance (Ccr), HUA is classified according to Cua/Ccr ratio as follows: >10% is excessive uric acid production type, <5% is poor uric acid excretion type, and 5% to 10% is mixed type. Gout and hyperuricemia patients don't need to know the typing method by themselves, but they need to know the reason of their high blood uric acid from their doctors: low uric acid excretion? Or is it more blood uric acid production? Choose a treatment plan according to your actual situation. Because dietary treatment can reduce blood uric acid by about 10% to 18% or lower blood uric acid by 70 to 90
Most patients will need medication. If a patient has hyperuricemia due to high blood uric acid production and chooses drugs that promote uric acid excretion: the concentration of blood uric acid passing through the kidneys per unit time increases, which may lead to kidney damage, kidney stones, etc. If a patient has high blood uric acid due to reduced uric acid excretion and chooses drugs that inhibit uric acid synthesis such as febuxostat and allopurinol: the patient has to suffer the side effects of the drugs, but the treatment is not effective. That is why it is important for patients with gout and hyperuricemia to know their subtype.