It is a typical clinical manifestation of stage I syphilis. In men, it usually occurs on the genital organs, such as foreskin, coronal groove, glans and ties, and is mostly solitary, but rarely multiple. The noma is usually a small red spot that gradually expands into a papule and then forms a hard node that is slightly hard to the touch, and when necrosis occurs, it can form a round or oval ulcer, mostly 1-2 cm. The chancre will be pigmented afterwards. If a patient has the above symptoms or suspects that he/she has syphilis, he/she should go to the hospital for clarification through pathogenic tests, serological tests and other related procedures. If the diagnosis is confirmed, it is necessary to take relevant drugs for treatment under the guidance of professional doctors, such as benzathine penicillin and procaine aqueous penicillin G, which are common. During the treatment period, patients should avoid excessive contact with people, and also forbid intercourse to avoid infecting others. In addition, a light diet should be taken and stimulating beverages such as alcohol, strong tea and coffee should be avoided to avoid aggravating the discomfort.