Mucocutaneous rash symptoms are commonly associated with syphilis infection. There are many people who believe that syphilis occurs at the genital organs, but in fact, syphilis grows in different places. The rash of syphilis grows not only on the coronal sulcus, foreskin, glans and scrotum of the penis, but also on the fingers, lips and inside the eyelids. The traumatic surface of stage I syphilis contains many syphilis spirochetes, and if the patient’s rash grows on the hands and shakes hands with others, it may be transmitted to others. Because the syphilis spirochete can enter the body through the broken skin mucous membrane, and many people are not aware that they have small injuries on their hands, so shaking hands with a syphilis patient is easy to “hit”. Even if the rash does not grow on the hands, syphilis patients urinate out without washing their hands and then shake hands with people can cause “trouble”. In order to prevent syphilis, we need to do some basic things that require the efforts of the whole society. 1, tracking the patient’s sexual partners. Including the patient’s self-reported and medical personnel visit, find all the patient’s sexual contacts, preventive examination, tracking and observation and necessary treatment, before the cure spouses are absolutely prohibited to have sex; 2, the suspected patients should be preventive examination. Do syphilis serological test, in order to early detection of new patients and timely treatment; 3, found syphilis patients must be forced to isolation treatment. Because this type of disease is a highly contagious disease, it is best to find patients for forced isolation treatment; if the patient is pregnant must be given timely preventive treatment to prevent patients from transmitting the virus to the fetus. Unmarried male and female patients can not be married before the cure. 4, to eliminate improper or unclean sexual relations and sexual behavior. This is also a common preventive measure for syphilis. It is better to use condoms. If you are unfortunate enough to have a history of syphilis contact, you must go to the hospital in time to do a serological examination for syphilis in order to find early treatment; if a sexual partner is found to have suspected syphilis symptoms, you must insist that the couple be treated together.