Syphilis is a typical sexually transmitted disease, mainly caused by infection with the syphilis spirochete, and both male and female patients will have a series of typical symptoms and complications. It is believed that the typical symptoms of syphilis vary depending on the stage, and can be specifically divided into one, two or three stages, while the complications are mainly dementia and spinal consumption: 1. Stage I syphilis: hard chancre appears mainly in the external genital area, mostly in the glans, foreskin and tethered area in men, manifesting as red rash or hard mass. Most of the lymph nodes in the groin or near the affected area are swollen, and the patient has no conscious pain. 2. Dark erythematous or desquamative macules are seen on the hands and feet, and flat warts on the genital and perianal areas, and there is hair loss, usually accompanied by itching. There may be skin mucosal ulcers, commonly in the mouth, throat or genitals, and there may also be general discomfort and generalized lymph node enlargement; 3. Stage 3 syphilis: nodular syphilis rash is common at this time, most often on the head, face, shoulders and back, and there may be severe skin damage such as syphilis tumors. Involvement to other parts of the body will show arthrogryposis or near-joint nodules in joints, skin, bones, etc. Systemic symptoms include abdominal pain, diarrhea, frequent urination, urinary urgency, and red eyes. It can also manifest as cardiovascular syphilis, syphilitic meningitis, spinal consumption, or paralytic dementia.