Gallbladder cancer is a rare type of tumor, but like sarcoma, regardless of the rarity of the tumor, cancer degree also feels that it is very necessary to sort out the basic treatment strategy of this disease, and in the concept of precision medicine, is it necessary to do genetic testing to guide the subsequent targeted drug use, and is it worth trying to use drugs across cancer types? Are there any new studies proving the effectiveness of certain existing targeted drugs? Gallbladder cancer is formed when certain cells of the gallbladder undergo genetic mutations and lose their normal growth regulation ability and become malignantly proliferating cancer cells. Gallbladder cancer is a relatively rare tumor. The gallbladder is a pear-shaped organ located in the upper abdomen just below the liver. The gallbladder stores bile made from the liver, which is used to digest fat. As food is broken down in the stomach and intestines, the gallbladder releases bile through a duct called the common bile duct, which connects the gallbladder and liver to the first part of the small intestine and serves as a link. The wall of the gallbladder has three main layers of tissue, the mucosal layer (inner layer), the muscular layer (middle layer), and the plasma layer (outer layer). Between these three layers is the supporting hoof tissue. Primary gallbladder cancer originates in the inner layer and gradually spreads and metastasizes to the outer layer as it grows. Generally speaking, women have a higher risk of developing gallbladder cancer than men. The treatment of gallbladder cancer needs to be considered according to various factors such as its stage, primary or recurrence, and the morphology of cancer cells under the microscope. Only when gallbladder cancer is confined to the primary site without metastasis can it be cured by surgery, while all other ways are conservative treatments aiming at increasing patients’ survival and improving their quality of life. Of course, science and technology are developing rapidly and there may be new technologies and treatments to control the tumor in the next few years, so no matter what, persistence is the hope. The gallbladder and its surrounding tissues, including nearby lymph nodes, can be removed through cholecystectomy. This surgical procedure is usually performed laparoscopically. If the tumor has spread and cannot be removed, then the following procedures may be used to improve quality of life Surgical biliary bypass, if the tumor growth is blocking the flow of bile to the small intestine, then this procedure needs to be performed where the gallbladder or bile duct is cut and sutured to the small intestine to create a new pathway to bypass the blocked area. Stent placement, if the tumor is blocking the bile duct, a stent (thin, flexible tube) can be placed to allow bile to flow out of the area that is blocked. The stent can be placed in a variety of ways, including being placed externally, around the blocked area, to drain the bile into the small intestine. Percutaneous hepatic puncture for biliary drainage is used as a strategy to unblock the bile if stent placement is not possible. to treat obstructive jaundice caused by the tumor.