Many studies have shown that depression and obesity have a two-way promotion effect. Compared with people who are not fat, people who are in a long-term obese state are more likely to have mood disorders, such as autism and depression, and these mood disorders will make them isolated from society, and if people around them also have attitudes of rejection and discrimination, they will further aggravate their mood disorders; and when people suffer from mood disorders such as depression, they may often overeat and become reluctant to exercise, leading to weight persistent increase, so that patients fall into a vicious circle. As an effective treatment for obesity, weight loss metabolic surgery can improve obesity at the physiological level and help obese patients lose a lot of extra weight within a year and return to a healthy state. In addition to the surgery itself, the post-operative management is also very demanding. After the surgery, patients need to go to diet and exercise under the advice of health managers and nutritionists in order to ensure the safety and effectiveness of the surgery, so those medical institutions that have carried out the relevant surgery for a long time have a perfect post-operative management system. If patients are depressed, they need to be psychologically evaluated before the surgery to ensure that they can cooperate with the health manager after the surgery. If after assessment and treatment they still do not qualify, the surgery is not recommended.