Erythromycin drugs, tetracycline drugs, andloxacin drugs can treat syphilis, but the preferred drug for syphilis is not the above drugs, but the long-acting benzathine penicillin. Benzathine penicillin is the most effective drug for syphilis, and no drug resistance has been found so far. Therefore, in the case of non-allergic penicillin, try to choose denatured penicillin for syphilis: 1, safe and effective. 2, affordable, and the course of treatment is relatively short. The treatment time of alternative drugs is longer, they are more than half a month, and you have to insist on taking them every day, and the effect of treatment is not always very good. Choose erythromycin or other drugs in case of penicillin allergy.