In outpatient work, more and more patients with abnormal liver function are found. Among the patients with abnormal liver function, besides toxic hepatitis and alcoholic liver disease, there are now many patients with drug-related liver damage, accounting for about 10% of the outpatient volume. I. So what is drug-related injury? Drug-related liver injury, as the name implies, is the drug or drug metabolites caused by liver damage. Due to the yearly increase in the number of new drugs and drug abuse, the incidence of drug liver has increased year by year, and has ranked fourth in liver disease. Second, are all drugs capable of causing liver injury? Our liver is the “detoxification factory” of drug transformation and metabolism, and is an important organ in the human body for synthesis, metabolism, decomposition and detoxification. We often say “my heart and liver baby”, so the liver is also our baby and must be taken care of especially. If a drug is taken without professional guidance, and if the dosage, indications, course of treatment and collocation are not reasonable, the liver is bound to bear the brunt of the toxic side effects after the drug enters the body. However, there are a few drugs that are mainly metabolized by the kidneys and have relatively little effect on the liver. Third, which clinical drugs can cause drug-related liver damage? There are six types of drugs that can easily damage our liver if not taken properly, including anti-tuberculosis drugs, lipid-lowering drugs, antibiotics, tumor chemotherapy drugs, antipyretic and analgesic drugs, sleeping pills and so on. Usually we have a cold and fever, headache, often go to the pharmacy to buy some drugs to eat, these drugs are safe? This kind of medicine in the major market pharmacy has a large number of sales, such as many people are familiar with the Crypto, New Contec, Compeed, Sensitive Health, White Plus Black, cold and flu pass, Tylenol, Benadryl, Teck, Sensitive, cold and fever punch and so on a series of products, this kind of medicine almost all contain antipyretic and analgesic ingredients, the most is acetaminophen. Acetaminophen is the number one killer of drug-induced liver injury in the United States. It can cause liver damage when taken in excess or over a long period of time. However, because most of the above drugs are compounded, the acetaminophen content is relatively safe. Therefore, we should pay attention to the medication we take, do not just buy the drugs outside, each person’s specific condition, the cause of the disease are different, or should go to the hospital to receive regular treatment and take the medication according to medical advice, do not arbitrarily increase the dose, extend the course of treatment or irregular use of drugs. During the medication period, the liver function should be checked regularly, and any changes in the original disease should be carefully observed, whether there are symptoms such as fatigue, nausea, vomiting, anorexia, hepatomegaly, liver pain, jaundice, rash, fever, chills, elevated bilirubin and transaminases. If liver damage has already occurred because of medication, stop the suspected drug immediately and seek medical attention as soon as possible, telling your doctor your recent medication history in order to determine the cause. Dear friends, please protect your “heart and liver”!