Take every step! ”Taking every step” means not only choosing the right tool to fight against hepatitis B in the long-term treatment process, but also paying attention to the long-term effects of treatment and establishing long-term treatment goals to achieve the goal of long-term treatment. The ultimate goal of chronic hepatitis B treatment is to obtain sustained inhibition of HBV replication and remission of liver disease, and to improve quality of life and survival by preventing disease progression of cirrhosis, decompensated cirrhosis, end-stage liver disease, liver cancer and death. Therefore, the treatment of chronic hepatitis B is long-term and arduous. In the course of long-term treatment, some patients may exhibit extreme mentalities that cause dangerous consequences: one is paralysis, ignoring the fact that the hepatitis B virus is difficult to clear. This state of mind is often present in patients who are more effective with antiviral therapy. They do not follow up with their doctors, do not take regular blood tests, do not take their medication regularly and stop it at will. It is well known that there are two major dangers associated with the use of nucleoside antivirals: drug resistance and rebound of the disease after discontinuation of the drug. If the patient neglects the follow-up, the doctor cannot understand whether drug resistance occurs and cannot formulate timely salvage measures; if the patient stops the medication at will, there is a risk of serious disease rebound and even life-threatening. The second type is extreme panic and apprehension and lack of confidence in treatment. These patients have certain psychological problems, they go around to see doctors and do not believe in their treatment plan, change the treatment drugs from time to time, or worse, think that it is better to take more drugs. As a result, not only the disease is not effectively controlled, but also drug-induced liver damage is produced, which makes the subsequent treatment extremely difficult and passive. The correct treatment mindset should be positive, optimistic and cautious. In the treatment, regular follow-ups (e.g. liver function and hepatitis B half and HBV DNA checks every 3 months) should be conducted under the guidance of the doctor, and medication should be taken strictly according to the doctor’s prescription, not for more but for the correct dosage. In this way, most of the adverse effects can be avoided or detected early and dealt with. In the follow-up, once the occurrence of adverse drug reactions (such as nucleoside drug resistance occurs), do not panic, as soon as possible, as soon as possible to seek medical advice, and the doctor to fully communicate, analyze the reasons for the occurrence, relaxed mind, correct treatment is the best way to cope with and solve the problem. Three major notes for treatment follow-up: 1. Easy life is indispensable: the purpose of treatment is to live a better life, but it is not the whole life. Should have the confidence to overcome the disease, with the help of doctors, relax and face positively. 2, the rapid success is not desirable: chronic hepatitis B treatment is a long-term process, must establish the correct form, take a scientific treatment plan, do not be “fast, stop, cure” and some other untrue words blinded. The quick success can only make half the effort. 3, do not stop the drug as the goal: temporary treatment effect is not the same as the disease cure, unauthorized discontinuation of the drug will make the disease repeated, not only delayed the treatment time will cause harm to health.