Ankylosing spondylitis is a chronic progressive inflammatory disease that primarily affects the spine and involves the sacroiliac and peripheral joints. These diseases start as tendon end inflammation, finger/toe inflammation or oligoarthritis, and in some cases may progress to sacroiliac arthritis and spondylitis with or without extra-articular manifestations such as acute anterior uveitis or skin mucosal damage. Inflammation at the beginning of the tendon is a characteristic manifestation of the disease. Swelling of the joint may not be evident in patients, but rather in non-articular or peri-articular areas, and is more common in areas with concentrated points of attachment such as the peri-shoulder, lumbosacral, chest, back, around the knee, heel area, and palmar area. Most patients have a very insidious onset, insidious means that they are unaware of the disease, many patients are difficult to determine the exact time of their illness, especially in patients with low back pain, at first it may only be low back discomfort, low back pain, mild back pain, even if some patients have obvious pain, but most of them occur at night or in the morning, a little activity will obviously reduce and not go to the doctor, so there are In fact, ankylosing spondylitis generally takes at least 2-3 years before spinal ankylosis occurs, and these two to three years are the key to treatment, so be alert to the above symptoms and strive for early diagnosis so that the disease is treated promptly in the nascent state is a prerequisite for a good outcome. In addition, a small number of patients, especially adolescent patients, may have a more urgent onset of the disease and usually have a urinary tract or gastrointestinal tract infection as a trigger. 70% of patients actually have these infections within 1-4 weeks before the onset or exacerbation of the disease, so prevention and control of infection is of particular importance in the treatment of the disease. A small number of patients may have eye inflammation, abdominal pain and diarrhea, oral ulcers, and skin erythema as their first manifestations, and the presence of these problems should alert them to the possibility of future ankylosing spondylitis. Experienced specialists will usually do some tests or directly advise patients to go to the rheumatology department to see if the disease is insidious, insidious in the sense that they are unaware of it. In fact, ankylosing spondylitis generally takes at least 2-3 years before spinal ankylosis occurs, and these two to three years are the key to treatment, so be alert to the above symptoms and strive for early diagnosis so that the disease is treated promptly in the nascent state is a prerequisite for good results. In addition, a small number of patients, especially adolescent patients, may have a more urgent onset of the disease and usually have a urinary tract or gastrointestinal tract infection as a trigger. 70% of patients actually have these infections within 1-4 weeks before the onset or exacerbation of the disease, so prevention and control of infection is of particular importance in the treatment of the disease. A small number of patients may have eye inflammation, abdominal pain and diarrhea, oral ulcers, and skin erythema as their first manifestations, and the presence of these problems should alert them to the possibility of future ankylosing spondylitis. An experienced specialist will usually perform some relevant tests or directly advise the patient to consult with a rheumatologist.