The spine, commonly known as the “backbone,” is connected to the skull, the middle to the rib cage, and the lower end to the hip bone to form the pelvis. The normal human spine has four spring-like physiological curvature from top to bottom, which keeps the body in balance, gives a cushion to the shock generated by movement, effectively supports and maintains the safety of internal organs, for the human body, it is a veritable “pillar”, whether the structure of the spine is in the best position to determine whether the body posture is upright. It is the dream of all of us to have an upright posture. However, relentless disease is silently destroying this beauty of health. What kind of disease is ankylosing spondylitis and how can it turn a person into a hunchback like an old man in a few years? Ankylosing spondylitis is a systemic disease, most patients are young men, early symptoms are mainly from the sacroiliac joint pain, up the spine, progressive concentration, with night pain, morning stiffness, sweating, wasting as the main symptoms. The patient often takes flexion of the knees, hips and waist as night pain cannot sleep, and over time, in the advanced stages of the disease, a posterior convex deformity of ankylosing spondylitis develops. x-ray manifestations include ankylosis of the sacroiliac joint and small joints of the spine, progressive aggravation of sclerosis, ossification of the fibrous ring, anterior longitudinal ligament, interspinous ligament and intervertebral plate ligament. As the disease progresses, after the inflammatory phase, the interlaminar and interspinous processes become bony ankylosis, and the pain in the spine gradually disappears, and finally the vertebral arches are ossified, producing bamboo-like changes. The normal lumbar lordosis often disappears and becomes lumbar lordosis, and the thoracic lordosis and cervical lordosis increase, forming an arc-shaped kyphosis that resembles the wheel of a bicycle on a lateral X-ray. The ankylosed deformed posture causes the patient’s head to bend forward and the center of gravity to shift forward in the standing position, affecting the patient’s uprightness and causing him to lose balance in the standing position. At the same time, the patient’s cardiopulmonary function is also affected due to the altered shape of the thorax. This structural spinal deformity affects both physiological function and causes psychological depression in patients. How can ankylosing spondylitis be detected early and treated effectively to prevent its continued progression? The onset of ankylosing spondylitis is relatively insidious, with patients gradually developing hip and hip or low back pain and stiffness, especially when lying down for a long time (at night) or sitting for a long time, difficulty turning over, and stiffness in the low back that is apparent in the morning or when rising from a sedentary position but decreases with activity. If you have these symptoms, it is time to go to the hospital. After some basic tests, especially HLA-B27, most patients can get a clear diagnosis. Ankylosing spondylitis requires long-term treatment, even lifelong treatment Proper walking, proper sleep posture, and lumbar and abdominal exercises can maintain joint flexibility, and breathing exercises and aerobic exercises such as swimming help maintain good lung function. At present, the western drugs Fotarim, Fenbendazole and Nimesulide have a better effect on the painful stiffness of ankylosing spondylitis. Lyuzosulfapyridine is effective for improving low back stiffness and sacroiliac joint lesions. Severe peripheral joint lesions can also be treated with methotrexate. However, these drugs do not completely prevent the occurrence of spinal deformities, joint ankylosis and even paralysis. The most effective western drugs are biologics, which not only significantly reduce the stiffness and pain caused by ankylosing spondylitis, but also effectively place the disease causing spinal joint destruction, joint ankylosis, and stop the progression of the disease. But the main drawback of biologics is that they are expensive.