For antidepressants such as paroxetine, there are these common rules: First, safety, in general, the safety of these drugs is relatively good, compared with the safety of many commonly used clinical drugs for the treatment of hypertension, hyperlipidemia, diabetes, etc., there is no particular gap. Second, the efficacy, the overall efficacy is good, most patients will have different degrees of improvement after taking the condition, but there will be a part of taking ineffective, or only a slight improvement in the condition. Third, individualized drug use is the key. If the clinical “suitability” of a drug is defined as the efficacy of the drug and the absence of adverse reactions that are clearly intolerable, then, first of all, it should be noted that no drug for any disease can be used for “all” patients with that disease. There will always be a small number of patients who take a drug that is ineffective, or who experience intolerable or potentially health-threatening adverse effects. If a patient takes a drug and either of these two conditions occurs, the drug is judged to be unsuitable for that patient and should be discontinued. Individual reactions to the same drug can vary greatly from person to person. Therefore, one cannot simply base one’s decision to take a medication on the experience of others. Clinically, there are often multiple medications for the same disease. Like antidepressants, there are more than 10 very commonly used drugs. Just because a depressed patient is “unsuitable” for a particular medication does not mean that he or she is unsuitable for other antidepressants and can switch to other medications. In some patients, the effect of one drug alone may not be satisfactory due to the complexity of the disease, and two or more drugs can be combined at this time. The range of indications for antidepressants, the first of course is the treatment of depression, in addition, many commonly used clinical antidepressants are also commonly used in the treatment of various anxiety disorders, obsessive-compulsive disorder, like paroxetine, sertraline, fluvoxamine, citalopram, escitalopram, fluoxetine, venlafaxine, etc. Severe and especially chronic anxiety, accompanied by depressive symptoms of anxiety, are suitable for the selection of antidepressants systemic treatment. Finally, all antidepressants are prescription drugs, so it is recommended that patients must use them under the observation and guidance of a doctor, and go to the hospital regularly for follow-up, and seek medical help in time to determine whether the drug is suitable and the time frame for treatment; at the same time, do not purchase and take the drug on your own, or stop taking it on your own decision. We wish all patients a speedy recovery.