As the disease progresses, the inflammation gradually moves to the lumbar and thoracic spine and eventually affects the cervical spine, resulting in a poor range of motion of the spine, initially with limited backbend and lateral bending, and in advanced stages with limited forward bending. Pain near the thoracic or cribriform joints is often present, mainly due to inflammation of the tendon attachments, which is similar to the pain of the rib cage. About a quarter of patients have hip arthritis, which can cause limited joint movement, difficulty squatting, limping, and unequal foot length. Tendon and ligament attachments to bones are commonly seen in Achilles tendonitis in the heel and plantar fasciitis in the sole of the foot, which can cause redness, swelling, and pain and even affect walking. Juvenile ankylosing spondylitis that develops before the age of 16 often begins with peripheral arthritis, especially in the knee, hip, ankle, or Achilles tendonitis of the heel or plantar fasciitis, and the typical symptoms of spinal arthritis gradually appear a few years later, and in these patients the peripheral arthritis is usually more severely invasive. In women with ankylosing spondylitis, the spinal joints and sacroiliac joints are usually less symptomatic, but there is early invasion of the peripheral joints or cervical spine, but the prognosis is usually good. Chronic inflammatory lower back pain is usually the earliest manifestation and is characterized by insidious episodes, pain that lasts more than three months, worsens with rest, and improves with exercise. Symptoms other than skeletal joints: 1. Uveitis will be combined with uveitis in about a quarter of patients, with inflammation of the iris-ciliary body in the anterior segment being the main cause. Symptoms include red eyes, photophobia, eye pain, tearing, blurred vision, etc., usually alternating between the two sides. There is no correlation with the severity of symptoms of spondylitis, and the prognosis is good, but if not treated properly, sequelae such as glaucoma or cataracts may occur. 2. Lungs: Poor expansion of the thoracic cavity, combined with severe spinal deformation, can cause restrictive lung disease, and in severe and long-standing patients, fibrosis of the upper lung lobes may occur. 3, Kidney: Some patients will have type A immunoglobulin nephropathy, but it is usually microscopic hematuria or proteinuria without symptoms, and most of them will not cause kidney failure. 4.Heart: A few patients will have mild aortic atresia and heart block, which are usually asymptomatic. 5.Intestinal tract: Some patients will have inflammatory colorectal disease with symptoms such as diarrhea or bloody stools, constipation, and abdominal pain. 6.Genitourinary tract: Some patients will have frequent inflammatory infections of the genital or urinary tract. 7, systemic symptoms: slight fever, fatigue, weight loss, etc. 8.Some patients may have symptoms of dry ringworm.