Depression self-assessment questions cannot confirm the diagnosis of depression because depression is diagnosed through three aspects, of which the Depression Inventory is only one. Because there are many artificial factors in the self-test questions, they do not reflect the overall state of mind of a person. Also, there are more causes of depression. Personality disorders are caused by interpersonal problems that lead to depression, and its different from traditional depression. Some depression is caused by medication, and it is not the major depression, persistent depression, etc. that is commonly thought of. Some depression is due to physical causes, such as thyroid problems, which can lead to depression. In addition, neurological diseases, such as neurocognitive dysfunction and Parkinson’s disease, may have early symptoms that are mainly emotional symptoms, which are not particularly well understood by the public and cannot be diagnosed by depression self-assessment questions. In the second aspect, it is also necessary to have the experience of a specialist to judge. The third aspect is that the doctor must also understand the extent to which depression itself affects the patient’s life and work, as well as the length of the illness. All these combined can diagnose depression.