Doxycycline tablets can treat acne. There are many aspects to the pathogenesis of acne, the most important cause being Propionibacterium acnes infection. Doxycycline belongs to the class of antibiotics and has a significant therapeutic effect on the inflammatory response caused by Propionibacterium acnes. However, there are many aspects of acne, including abnormal follicular mouth keratinization, high androgen levels, and high sebaceous gland secretion. Therefore, the treatment of acne cannot simply use antibiotics, but also needs to be combined with other drugs to deal with the different onset and relief of acne, such as oral isotretinoin to regulate follicular mouth keratinization, oral vitamin B2 and B6 to reduce sebaceous gland secretion, such as High androgen levels require oral anti-androgen drugs for comprehensive treatment. Therefore, acne can be treated with doxycycline, but not only with doxycycline.