In view of the recent increase in the number of pregnant patients during pregnancy; and seeing that a considerable number of pregnant women are abandoning their fetus because of a positive syphilis serology detected during a physical examination during pregnancy, we would like to share the following information and appeal to pregnant patients with syphilis during pregnancy: Please do not abandon your fetus in the womb (especially if it is RPR or TRUST negative), because syphilis during pregnancy is treatable. In early pregnancy, treatment is aimed at keeping the fetus free from infection; in late pregnancy, treatment is aimed at curing the infected fetus before delivery and also treating the pregnant woman. Mothers who have delivered a child with early fetal syphilis, although they have no clinical signs and are seronegative, still need to be treated appropriately. The treatment principles are the same as for non-pregnant patients, except that tetracycline and doxycycline are contraindicated. Recommended regimen 1. lucaine penicillin G, 800,000 U/d, intramuscularly for 15 d. or benzathine penicillin G 2.4 million U, divided into two gluteal intramuscular injections, once weekly for 3 d. Alternative regimen 2. For penicillin allergy, treat with erythromycin (tetracycline is prohibited); or ceftriaxone 250-500mg (1g is also used) intramuscularly once daily for 10d. The above regimen is applied for one course of treatment during the first 3 months of pregnancy and one course of treatment during the last 3 months of pregnancy. After treatment, a quantitative RPR test was performed once a month to monitor for recurrence and reinfection. If the RPR or TRUST titer does not decrease by 2 dilutions (4-fold) or increase by 2 dilutions (4-fold) within 3 months, treatment should be repeated. After delivery, follow up will be performed as a general syphilis case. Follow-up of infants born to pregnant women with syphilis: 1. Infants born to pregnant women with syphilis who have undergone adequate treatment: ① At birth, if the infant is seropositive and does not exceed the mother’s serum titer, it should be rechecked once a month; at 8 months, if it is negative and there is no clinical manifestation of fetal syphilis, observation can be stopped. ②If the baby is born with negative serum reaction, it should be retested at 1 month, 3 months and 6 months after birth, and if it is still negative at 6 months and there is no clinical manifestation of fetal syphilis, syphilis can be excluded. If the titer rises gradually during the follow-up period, or if the clinical manifestations of fetal syphilis appear, the patient should be treated immediately. 2.Infants born to pregnant women with syphilis who have not been adequately treated or not treated with penicillin, or those who are not in a position to follow up their infants, may be treated with prophylactic syphilis for the infants and supplementary treatment for the pregnant women.