In recent years syphilis in pregnancy is becoming more and more common in the clinic, here is a brief description of the considerations and treatment options for syphilis in pregnancy: 1. Most syphilis in pregnancy is asymptomatic latent syphilis, so early in pregnancy we should do a syphilis serologic test for screening. The test is optimal for RPR, the titer is very important, and auxiliary TPPA test to confirm the diagnosis. 2. The treatment of syphilis in pregnancy is still preferred to penicillin treatment. Other treatment options such as erythromycin, ceftriaxone sodium and azithromycin are poor. The serological review of syphilis in pregnancy is very important, before and after penicillin treatment in early pregnancy, and before penicillin treatment in late pregnancy are required serological examination. 4, syphilis in early pregnancy is the most destructive to the fetus, treatment must pay attention to prevent Jihai reaction, can take oral prednisone tablets. 5, the postpartum fetus must be regularly tested for syphilis serology and preventive treatment.