Treatment is essential for mankind to overcome disease, and drugs are one of the most effective weapons. However, mankind should face the fact that treatment is a double-edged sword, which can cure the patient; at the same time, it may also bring adverse reactions to certain organs of the body, even life-threatening adverse reactions (such as the familiar drug penicillin, whose application has so far saved the lives of countless patients, but some people have lost their lives because of it); and these adverse reactions, just like human beings who are sick, are either predictable or unpredictable. Some are predictable and some are unpredictable; just like living in the same environment, some will get sick and some will not. The main reason for this is that it depends on the result of the interaction between the human body and the drug (environment), and the genetic characteristics of the individual are still dominant and unpredictable; with the continuous development of medicine and the increasing awareness of human beings, this unpredictability will be greatly improved in the near future. The definition of adverse drug reactions: refers to any harmful reactions (including allergic reactions, drug dependence, tissue and organ damage, mutations, carcinogenesis, teratogenesis, disability, death, etc.) that occur under the normal dosage of qualified drugs in order to prevent, diagnose or treat human diseases and improve human physiological functions. At the same time, the following two points should be emphasized: 1, it does not include harmful reactions caused by the quality of drugs, overdose, improper route and method of administration of drugs. 2. The content and statistics of the adverse drug reaction report are the basis for strengthening drug supervision and management and guiding the rational use of drugs, and are not used as the basis for medical accidents, medical lawsuits or dealing with drug quality accidents. Drug-induced liver disease (referred to as drug liver) is one of the most common manifestations of adverse drug reactions, it refers to the application of therapeutic doses of drugs in the treatment process caused by liver damage, including drugs directly or indirectly caused. Its clinical subtypes are 1, hepatocellular type 2, cholestatic type 3, mixed type; the pathogenesis is not yet fully understood; the diagnosis of drug liver is currently limited to clinical diagnosis, there is no reliable diagnostic techniques and methods, based only on clinical experience (emphasis on adverse drug reactions) and exclusionary diagnosis; if necessary, liver aspiration biopsy is feasible (only to assist in diagnosis, mainly to exclude the original liver disease). Most of the treatment is not specific and effective, but most of the drug liver can be fully recovered with general symptomatic treatment and the prognosis is good. The timely discontinuation of any suspected drugs or chemicals (including house renovation, etc.) should be emphasized as the key to successful treatment and is the purpose of my effort to teach the basics of drug liver in different forms on different occasions; at the same time, appropriate symptomatic treatment should be taken, and serious cases should be promptly consulted and treated to prevent complications and concomitant diseases and improve the patient’s prognosis. The following points should be noted by both doctors and patients in order to minimize the occurrence of drug liver and improve the prognosis of drug liver. 1. Attention should be paid to the rational use of drugs for people at risk of drug liver; people at risk of drug liver include: (1) people with a history of adverse drug reactions; (2) elderly people or young children; (3) women; (4) simultaneous use of multiple drugs; (5) disorders of the body’s immune function (such as suffering from SLE, etc.); (6) patients with liver disease; (7) malnutrition; (2) people with the following symptoms after using drugs or being exposed to chemical products should not be neglected: nausea, weakness loss of appetite, yellow urine, jaundice, etc.; blood should be drawn promptly to check liver function. 3, clinical treatment with drugs should adhere to: can not use drugs as much as possible; can use less drugs as little as possible; when necessary, try to use the patient’s previous drugs, the use of drugs must be specific, individualized, do not arbitrarily change or increase the drug (even if the patient initiative), there is no best drug, only the most suitable for the individual patient’s medicine. 4, empirical drug use, habitual drug use is one of the good measures for clinicians to reduce adverse drug reactions, with their familiar drugs. Be sure to learn more about the overall state of the patient before using the drug; patients should take the initiative to tell the attending physician their situation without reservation, even if it belongs to the private part, rather than preconceptions and ask the physician to do something for you, which can only harm the patient himself. The physician should customarily ask the question “Is there any medicine you can’t use before?” before prescribing the medicine. This sentence is very important and useful. 5, the use of drugs or exposure to chemical products after changes in the condition should be considered whether there are adverse drug reactions, if so (even if suspected) should be promptly discontinued the suspected drugs and chemical products, and other appropriate measures. 6, there are data showing that the top five common types of drugs that cause drug liver: (1) anti-tuberculosis drugs (43, 78%); (2) Chinese medicine (16, 17%); (3) anti-microbial drugs (12, 60%); (4) anti-hyperthyroidism drugs (5, 60%); (5) anti-tumor drugs (5, 11%); I am concerned about adverse drug reactions for many years, especially drug liver injury; I have successfully applied for Guangdong Province and national I have successfully applied for Guangdong Province and national “clinical adverse drug reactions” study class for four years, the content is the main adverse drug reactions and the performance of adverse drug reactions in various specialties, by senior professors of various specialties working in the first line of clinical long-term, to share their personal experience and combined with the latest theoretical advances, has won the praise of colleagues; welcome colleagues with common interest in reducing clinical adverse drug reactions and common struggle We will strive to create a harmonious doctor-patient relationship, create a good working atmosphere for ourselves, and finally achieve a win-win situation for both doctors and patients.