The main cause of gallbladder cancer is gallbladder stones, especially cholesterol stones and particularly large gallstones. In clinical cases, about 75-90% of patients suffering from gallbladder cancer have gallstone disease. In addition, S. typhi infection and intestinal fistula are also risk factors for the development of gallbladder cancer. So, how can we keep away from gallbladder cancer? Besides taking necessary preventive measures, knowing its early symptoms can also nip it in the bud. Gallbladder cancer symptom 1: pain in right upper abdomen Among the patients with gallbladder cancer, about 80% of them have pain in right upper abdomen. The pain is mostly dull and will be aggravated after meals; occasionally, colic pain may also appear, which is gradually aggravated. Gallbladder cancer symptom 2: right upper abdominal mass When the tumor is located in the neck of gallbladder or the combined gallbladder stone obstructs the gallbladder duct, it may cause enlargement of gallbladder and acute cholecystitis. If there is a lump with uneven surface, hard texture and immobile in the right upper abdomen, it is necessary to do gallbladder cancer screening in time. Gallbladder cancer symptom 3: Jaundice Jaundice is the most typical symptom of gallbladder cancer, and almost all gallbladder cancer patients will have different degrees of jaundice, mainly manifested as yellowing of sclera and skin. This jaundice is progressively aggravated and mostly painless, and only a few patients show fluctuation. Gallbladder Cancer Symptoms IV: Other Some patients may have upper gastrointestinal bleeding, and when the tumor invades the colonic hepatic flexure, gastrointestinal obstruction may occur. When the tumor compresses the portal vein, it may also cause portal hypertension. Some patients may also experience weight loss, nausea, vomiting and other symptoms, which are often ignored because they are relatively common. Clinically, jaundice, right upper abdominal mass and right upper abdominal pain are called “triple signs”, when these three symptoms appear at the same time, it can almost be judged as gallbladder cancer. If the above symptoms are not obvious, or only one or two of them appear, it cannot be confirmed as gallbladder cancer, and the following medical methods are needed to confirm the diagnosis. Tumor markers: CEA and CA19-9 will be positive in both blood and bile of gallbladder cancer patients, from which gallbladder cancer can be initially diagnosed. Moreover, the value of CEA and CA19-9 will gradually increase with the development of the disease. B ultrasound: B ultrasound is the most commonly used method to diagnose gallbladder cancer in clinical practice, with an accuracy rate of over 85%. It can directly detect early and progressive gallbladder cancer. CT: Although CT is less sensitive than B ultrasound, it can observe the wall of gallbladder. If there is any doubt about the diagnosis of gallbladder cancer in CT plain scan, it can enhance the scan, so as to improve the diagnosis rate of gallbladder cancer. In addition to the above three methods, cholangiography, arteriography, MRCP and ERCP can also be used clinically as auxiliary examinations for gallbladder cancer. Like other malignant tumors, the preferred treatment for gallbladder cancer is surgery, but it is only effective for early-stage tumors, while for advanced gallbladder cancer, the resection rate is low and the efficacy is not as satisfactory. Therefore, early detection and regular treatment is the most important method to eradicate gallbladder cancer.