In normal people, the skin is soft, smooth and elastic, which ensures that the joints bend, stretch and move freely. However, in some people, the skin of certain areas or even the whole body gradually becomes hard, taut and loses its elasticity to the point that it eventually affects joint movement. This disease is known medically as scleroderma. In some patients, only skin sclerosis occurs, which is called limited scleroderma, while in others, fibrosis and sclerosis of internal organs such as the heart, lungs, gastrointestines and kidneys also occur, a condition known as systemic scleroderma, which is often severe and has a poor prognosis. The cause of scleroderma is still unknown, but studies have found that some patients may be genetically linked to chromosomes; some patients also have lupus erythematosus or dermatomyositis or rheumatoid arthritis, among other diseases. It is known that many antibodies are present in the blood of these patients. Instead of fighting against foreign pathogens, these antibodies fight against their own tissues, cells or cellular components, which is a “self-inflicted” phenomenon, resulting in various tissue damage and destruction. The medical term for this disease is autoimmune disease. Many patients with scleroderma also have autoantibodies in their bodies, such as anti-Sc170 antibodies, anti-RNP antibodies and anti-synovial antibodies. But the causes of the disease are many. The earliest manifestation of this disease in most patients is purple and white with pain and numbness when the hand (toe) fingers are cold, which is called Raynaud’s phenomenon in medical science. This is due to narrowing and occlusion of the lumen of the small arteries combined with vasospasm in the cold. The skin of the trunk and extremities soon becomes diffusely swollen, then sclerotic, and eventually atrophied and thinned. As the subcutaneous tissues and muscles also atrophy and harden, the skin clings to the periosteum and skin ulceration and necrosis often occur. The patient’s facial expression is fixed, the nose becomes smaller and sharper, the eye fissures become smaller, the outer ear thinner, and the open mouth is involved. Pain and stiffness may be present in joints throughout the body. When the patient’s internal organs are involved at the same time, various corresponding symptoms often appear, such as difficulty in swallowing when the esophagus is involved; abdominal pain, diarrhea and constipation alternately when the stomach and intestines are involved; emphysema and dyspnea when the lungs are involved; shortness of breath, chest tightness, palpitations and various arrhythmias when the heart is involved; hematuria, proteinuria, azotemia and hypertension when the kidneys are involved. Such patients are in serious condition and need active treatment. There are many treatment methods and drugs for scleroderma, and the efficacy varies from person to person. Many patients can get some improvement and relief after daily recuperation and proper medication. Patients themselves should establish confidence in overcoming the disease, require a regular life, avoid excessive tension, various stimuli and smoking, and avoid the use of drugs such as ergometrine and epinephrine. Prevent trauma to the hand and avoid factors that induce or aggravate vasoconstriction. Pay attention to hand warmth and moderate finger and toe activities. Topical medications such as petroleum jelly, antibiotic ointment and urea grease should be used frequently to protect the skin. Pay attention to the combination of work and rest, increase nutrition, into the high protein, high energy diet. May scleroderma patients live and work like normal people.