Scleroderma is a connective tissue disease characterized by inflammation, degeneration, thickening and fibrosis of the skin leading to sclerosis and atrophy, which can cause multi-system damage. In addition to degenerative lesions of the skin, synovial membranes and finger (toe) arteries, internal organs such as the digestive tract, lungs, heart and kidneys can also be involved in systemic sclerosis. Systemic sclerosis is a chronic multisystem disease. Initial symptoms are often nonspecific and include Raynaud’s phenomenon, malaise, and musculoskeletal pain, which persist for weeks or months before other indications appear. The early clinical manifestations of scleroderma with specificity are swollen and thickened skin, beginning in the fingers and hands. This is followed by a variety of manifestations, mainly in the skin, lungs, heart, gastrointestinal tract or kidneys. The risk of renal involvement is increased in patients without Raynaud’s phenomenon. Scleroderma can be divided into several subtypes according to the degree of skin invasion: 1. Patients with limited scleroderma have only thickened skin on the distal extremities and no trunk invasion; the CREST syndrome, which includes: calcium deposits, Raynaud’s phenomenon, esophageal dysfunction, fingertip sclerosis and capillary dilation, is classified as limited scleroderma. 2. 2. Patients with diffuse scleroderma present with thickened skin on the distal and proximal extremities and/or trunk. Diagnosis 1. Main criteria Proximal scleroderma, i.e. symmetrical thickening, tightening and sclerosis of the skin from the end of the fingers (toes) to the proximal part of the metacarpophalangeal (toe) joint. Such changes can involve the entire limb, face, neck and trunk (chest and abdomen). 2, secondary criteria (1) finger scleroderma, the above skin lesions are limited to the fingers. (2) Depressed scarring of the fingertips or loss of tissue in the finger belly. (3) Bilateral interstitial lung fibrosis. Chest radiographs show linear or nodular shadows in a network of bilateral lung bases, which may have a “honeycomb lung” appearance. The diagnosis of scleroderma can be made if the primary criteria or two or more secondary criteria are met, and the various subtypes should be subdivided. CREST syndrome can be confirmed if three or more of the clinical manifestations of CREST syndrome are met, and if the anti-synovial antibody is positive.