This is probably the first question every patient asks when they get sick, and every doctor considers this question before treating a patient, so why do people get ankylosing spondylitis? It would be frustrating if I told you that it is not really clear why people get ankylosing spondylitis, but it is true that, like tumors, diabetes, hypertension and other rheumatic diseases, we do not currently know what their true mechanisms are. But what are so many biologists and medical scientists working on? In fact, contemporary advances in medicine have brought the truth about disease infinitely closer, and it is believed that the process of disease is generally clear, but only the key aspects of it need to be further explored. Understanding this basic process will of course also help in the development of preventive and curative measures in the river. A person has or does not have ankylosing spondylitis, first of all, there is no quality of the disease, that is, the genetic background, only with this background there is the possibility of suffering from this disease, a person need not worry about this quality of the problem, because no one’s genes are perfect, you either have this defect or that defect, it is impossible to have the perfect genes, which is also able to ensure that the premise of human evolution This is a prerequisite for human evolution. In fact, there may not be anything perfect in the world, and perfection is something to be sought, not to be had. Then having this quality does not mean that a person will definitely get the disease, just as many patients have a family history, and many more have searched for generations without finding the same sick relatives. Whether one gets the disease or not is also influenced by the acquired environment, which is a common pathogenesis of diseases like tumors, hypertension, diabetes and other rheumatic diseases. What factors actually influence this process? It is now believed that some factors that are sufficient to affect the immune system and the body’s self-stabilizing system can be considered a blow, such as infections of the respiratory tract such as colds, infections of the digestive tract such as diarrhea, and infections of the urinary tract caused by unclean behavior are the biggest blows to the immune system, so most patients often have a trigger for infection before they get the disease. Other factors such as irregular life, imbalanced living, poor diet, emotional depression, excessive mental stimulation, etc. may affect the self-stabilization system, which can be considered as a blow to the immune and self-stabilization system. It seems to come very suddenly, but in fact it is a slow and gradual process, the result of the accumulation of the above factors. Similarly, the removal of the above-mentioned factors is not a one-time thing. This is the essence of disease as we understand it, although many diseases can not yet fully explain where the trigger point from quantitative to qualitative change is, but the disease does happen in this way, whether from the perspective of prevention or cure, efforts to restore balance and stability of the body is the essence, so emotional optimism, not angry, regular life, less late at night, to prevent colds and less infections can maximize the stability of the human body to play The purpose of disease prevention and treatment.