The incidence of gallbladder stones in China is increasing significantly, and the incidence rate in Shanghai is close to 10%, with a female to male incidence ratio of about 2.57:1. Gallbladder stones are more likely to be found in people with high-fat diet, obesity, estrogen use, women with multiple pregnancies, long-term parenteral nutrition, diabetes, hyperlipidemia, etc. Clinical manifestations: A large proportion of patients with gallbladder stones are asymptomatic and are often detected incidentally during health examinations or consultations for other diseases. In patients with symptoms, the typical attack is paroxysmal or persistent colic in the right upper abdomen after a full meal or eating fatty food, often accompanied by involvement pain in the back of the right shoulder. In addition to this, patients with gallbladder stones may usually have dyspeptic manifestations such as vague pain in the right upper or mid-upper abdomen. Diagnosis: Ultrasound is the first choice for the diagnosis of gallbladder stones, with an accuracy rate of more than 95%. ultrasound can generally help doctors understand the size, number and location of gallbladder stones and whether the gallbladder is in an inflammatory phase. Although CT and MRI can also assist in the diagnosis of gallbladder stones, because CT may miss some negative stones, and MRI is not as sensitive as B ultrasound for small gallbladder stones, clinical diagnosis is generally recommended for patients to undergo ultrasound examination under fasting conditions. Treatment: As for the treatment of gallbladder stones, there are two types of treatment: symptomatic and asymptomatic. If the patient has a typical history of acute cholecystitis attack – paroxysmal or persistent colic in the right upper abdomen after a full meal, with pulling pain in the right shoulder or back, which is clinically referred to as “biliary colic” – surgical treatment is recommended. Some patients have symptoms without a typical history of acute attacks, such as vague pain in the upper and middle abdomen, indigestion, fullness and discomfort, etc. In the absence of clear indications for surgery, we recommend patients to complete relevant tests (such as gastroscopy, colonoscopy, etc.) to exclude gastrointestinal-related diseases before considering surgery for gallbladder stones. Does it mean that as long as there are no symptoms, gallbladder stones do not need surgery? Of course not. If any of the following conditions are met, surgery is required even if there are no symptoms of gallbladder stones (1) gallbladder stone size over 2.5cm or even filled stones; (2) gallbladder atrophy; (3) gallbladder wall calcification; (4) limited thickening of gallbladder wall; (5) combined with gallbladder polyps; (6) medical history over 10 years; (7) combined with diabetes. Features of our department: laparoscopic cholecystectomy has been widely used in clinical practice as the standard treatment for gallbladder stones, and our department has established a day surgery ward based on continuous innovation and optimization. That is, patients complete all preoperative examinations before admission, operate on the same day of admission, and can be discharged home to recuperate the next day. At present, all patients under 60 years old with simple gallbladder stones and in good general condition use this model, which is welcomed by the majority of patients and their families. Laparoscopic cholecystectomy is a minimally invasive surgical approach in which three or four “holes” are created in the patient’s abdomen to complete the surgery. Patients with a history of abdominal surgery are often unable to undergo laparoscopic surgery. After long-term surgical experience, our hospital now has a higher success rate of laparoscopic surgery for patients with a history of surgery and complex and difficult gallbladder surgery, and patients recover well after surgery. Patients with acute cholecystitis attacks often required open cholecystectomy in the past, while our hospital uses percutaneous transhepatic cholecystocentesis (PTGBD) to relieve acute inflammation, and laparoscopic surgery is performed after the inflammation subsides, with the same good results. Our department treated a 56-year-old male patient who came to our outpatient clinic with gallbladder stones about 2 cm in size, 3 mm thick gallbladder wall and calcification without any complaints of discomfort, as found by ultrasound during a physical examination at the unit. He was admitted to our day ward on the basis of ultrasound confirmation and the absence of stones in the common bile duct, and underwent uniportal laparoscopic cholecystectomy successfully.