The liver is the largest digestive organ in the human body, and underneath it is the gallbladder. The liver can produce a yellow-green liquid called bile, which is about 800ml per day, and then through a series of small and large bile duct systems, it is transported out of the liver into the gallbladder for concentrated storage, and when the body needs it, such as eating, the gallbladder contracts and discharges bile, which is a digestive fluid with the effect of emulsifying fat, and has an important role in the digestion and absorption of fat. It has an important role in the digestion and absorption of fat. The intestine and the gallbladder are connected by a common bile duct, and the gallbladder is like a pavilion on the river of the bile duct, in which the bile can stay and rest, and the gallbladder is actually a container, a transit station. The liver and the gallbladder are two important organs in the human body, interdependent and coordinated with each other. Once either the liver or the gallbladder suffers from a disease, the other can be involved. For example, a stone in the bile duct or a biliary roundworm can lead to retrograde infection of the liver. Conversely, the functional state of the liver can affect the gallbladder. Bacteria or viruses absorbed from the intestine into the liver via the portal vein can be destroyed in the liver if the liver is not functioning well, and can then flow through the bile to the gallbladder, leading to acute and chronic gallbladder infections. Thus, it can be seen that liver and gallbladder are indeed a pair of comrades who share the same boat and suffer together, so the relationship between them can be described as “liver and gallbladder, honor and disgrace together” is more than appropriate. Will liver disease cause gallbladder disease? There are large studies at home and abroad that found that people with fatty liver have a significantly higher chance of having gallbladder polyps or gallbladder stones than normal people. This is probably due to the fact that fatty liver patients tend to have a high-fat diet or accumulation of fat in the body, which leads to an increase in the concentration of cholesterol in the body, because there is only one way to excrete cholesterol in the body, which is to dissolve it in bile and excrete it out of the body through the bile duct into the intestines. The amount of cholesterol that can be dissolved in bile is closely related to the amount of lecithin in the bile. Lecithin can only be synthesized by the liver, and if you have fatty liver, the liver function will be impaired and the ability to synthesize lecithin will be reduced, so the lecithin in the bile will be greatly reduced, which will lead to less cholesterol dissolved in the bile, and the cholesterol in the gallbladder will be supersaturated, and cholesterol will precipitate in the bile and form cholesterol polyps or stones in the gallbladder. In addition, when fatty liver is combined with gallbladder stones, the gallbladder stones can promote and strengthen the inflammatory changes of fatty liver, strengthen the degree of liver damage and make the condition worse. It has also been found clinically that people with cirrhosis are at least twice as likely to develop gallbladder stones as non-cirrhotic patients. Why do people with cirrhosis tend to develop stones? There may be many reasons for this, the most important being the abnormal gallbladder dynamics in cirrhosis, the bile cannot be emptied in time, and the longer it is retained in the gallbladder, the more chances of precipitation and precipitation of stones. Secondly, the impaired function of hepatocytes leads to a decrease in bile acid secretion and a decrease in bile acid and bile salts in bile, which leads to a relative increase in cholesterol content. In addition, hepatitis virus or bacterial toxins can directly invade the gallbladder with bile or cause acute and chronic inflammation of the gallbladder due to immune response. These factors make people with cirrhosis of the liver prone to gallbladder stones and chronic cholecystitis. Most acute and chronic liver diseases of various causes cause gallbladder lesions, and the greater the substantial liver damage and the longer the duration of the disease, the higher the chance of gallbladder morbidity. Can gallbladder disease also cause liver function damage? Gallstones are the main cause of most gallbladder diseases. Gallbladder stones or the combination of acute and chronic cholecystitis can cause the gallbladder to lose its normal contraction ability, reduce its emptying ability, and fail to relieve the pressure in the bile duct in time, which in turn causes the pressure in the bile duct to rise, stagnating bile in the liver and causing liver damage over time when liver cells are immersed in bile. Once the stones floating in the gallbladder block the lower end of the cystic duct or common bile duct, the symptoms appear. In acute attacks of gallbladder disease, the right upper abdomen hurts and may radiate to the back and under the right scapula. Fever, chills, vomiting, and possibly acute liver function impairment or even jaundice may occur. Some people have also been suffering from intermittent epigastric pain and discomfort for many years, with repeated impairment of liver function, and have been treated as gastritis or hepatitis in the hospital, but the symptoms are never completely relieved, and the disease follows them like a shadow, causing endless troubles for the patient Some, after MRI examination, it was found that many people suffer from obstruction of the lower end of the common bile duct due to common bile duct stones, resulting in poor bile outflow and thus liver function impairment. The depth of jaundice varies with the degree of stone impaction, because stones in the common bile duct are like pistons and can go up or down, making jaundice “intermittent”, after all, complete impaction is still relatively rare. Therefore, patients with bile duct stones must be treated promptly to avoid critical illnesses such as acute obstructive purulent cholangitis and severe pancreatitis, which may increase the death rate.