I often hear friends around me ask what to do if their semen does not liquefy, but I don’t know much about its liquefaction time, and many of them don’t even know that semen has the process of coagulation to liquefaction. Today we will talk about semen liquefaction. What is non-liquefaction of semen? Failure to completely liquefy semen within 60 minutes after ejaculation or liquefaction that takes more than an hour to begin is called abnormal or delayed liquefaction of semen. Why is there a process from coagulation to liquefaction? Semen ejaculated by the human body quickly solidifies into a thick jelly state so that semen is not lost immediately after ejaculation into the vagina. The liquefied semen then seems to release the sperm to be free and begin the long journey to find the egg. What is the mechanism of normal liquefaction? The liquid part of semen mainly consists of seminal vesicles and prostatic fluid, the former accounting for 60%-70% and the latter accounting for 20%-30%. After ejaculation into the vagina, semen starts to liquefy from about 5min-30min, with jelly-like rapidly evolving into semi-jelly-like and finally liquefied. This regulation of coagulation and liquefaction is mainly balanced by the pair of factors secreted by the prostate and seminal vesicles. The coagulation-related factors originate from the seminal vesicles in 50%-80%, the liquefaction-related factors from the prostate in 15%-40%, and the testes and epididymis in 5%. Factors in the prostate include tryptokininogenase, chymotrypsin, alpha-amylase, and prostate-specific antigen (PSA, also a protein hydrolase). After contact with the seminal vesicle fluid and ejaculation into the vagina, the gel protein of the seminal vesicle is hydrolyzed and usually liquefies completely within 5-20 minutes. What are the usual causes of non-liquefaction? When prostatitis or infection of the reproductive tract occurs, the amount and activity of protein hydrolase in the prostate fluid decreases, resulting in a lack of liquefaction. How is it treated? The cause treatment generally requires anti-infection treatment, if accompanied by chronic prostatitis patients need to pay attention to the preferred fat-soluble good antibacterial drugs, such as quinolones and memantine. In addition drug treatment can also be treated with chymotrypsin, pancreatic kinase releasing enzyme and other intramuscular injections, vitamin C each time 0.6-1.0g, three times a day oral treatment. The combination of etiological treatment and Chinese medicine treatment for liquefaction often gives better results. Is there any other method? Couples who continue to have children may choose to process the male partner’s semen by artificial insemination before performing AIH (artificial insemination by husband).