Semen is not liquefied, a pathological phenomenon, which means that semen remains jelly-like for more than 30 minutes after it is expelled from the body. The common causes of semen non-liquefaction are insufficient fibrinolytic enzymes secreted by the prostate gland due to seminal vesiculitis and prostatitis; deficiency of trace elements (magnesium, zinc, etc.); congenital prostate deficiency, etc. It is generally believed that the secretions of the prostate and seminal vesicles are involved in the process of coagulation and liquefaction of semen. The coagulation factors produced by the seminal vesicles cause the coagulation of semen, while the liquefaction factors such as proteolytic enzymes and lyso-fibrinolytic enzymes produced by the prostate cause the liquefaction of semen. Once the inflammation of seminal vesicles or prostate occurs, the secretion of the above factors may be impaired, resulting in an increase in coagulation factors or a decrease in liquefaction factors, resulting in semen non-liquefaction. The most common causes of sperm non-liquefaction are insufficient fibrinolytic enzymes secreted by the prostate gland due to seminal vesiculitis and prostatitis; deficiency of trace elements (magnesium, zinc, etc.); congenital prostate deficiency, etc. It is generally believed that the secretions of the prostate and seminal vesicles are involved in the process of coagulation and liquefaction of semen. The coagulation factors produced by the seminal vesicles cause the semen to coagulate, while the prostate produces proteolytic enzymes, lyso-fibrinolytic enzymes and other semen liquefaction factors to liquefy the semen. Once the inflammation of seminal vesicles or prostate occurs, the secretion of the above factors may be impaired, resulting in an increase in coagulation factors or a decrease in liquefaction factors, resulting in sperm non-liquefaction. Therefore, in the treatment of sperm non-liquefaction, it lies in the eradication of seminal vesicle and prostate gland diseases. Most patients will also get better with sperm non-liquefaction after the prostate and seminal vesicle diseases are cured. Common causes 1, the lack of trace elements: if the male friend body of trace elements such as magnesium, zinc, etc. lack. This is also an important cause of sperm non-liquefaction. 2, congenital diseases: many congenital diseases can cause men to have semen not liquefied. When patients have congenital prostate deficiency, it will affect the production of prostate and proteolytic enzymes and so on, without the catalysis of these substances will lead to semen not liquefied. 3, irregular life: because of work, many men’s life time is not fixed, long-term stay up late, but also easy to directly cause the semen is not liquefied, thus causing male infertility. Symptoms 1, semen will be sticky, or will show a jelly state, will appear flaky, lumpy and mass, in vitro for more than an hour does not carry out liquefaction. 2.Symptoms of difficult ejaculation, accompanied by painful ejaculation, hematemesis and other manifestations, and even impotence, premature ejaculation and seminal emission may occur. 3.It leads to poor mental state and neurasthenia, such as insomnia, palpitation, dizziness, easy fatigue, etc. Not only that, but also some complications will occur. Diagnostic criteria Liquefaction time: less than 30 minutes; abnormal liquefaction refers to the phenomenon that semen cannot be completely liquefied at least half an hour after ejaculation or begins to liquefy more than an hour later, it includes semen non-liquefaction and delayed semen liquefaction, which are collectively referred to as semen non-liquefaction in the customary way. Scientific examination is an important measure to correctly diagnose the disease. It is also essential to treat the disease. A. Immunological examination should be done for sperm liquefaction: Immunological examination can determine the presence of autoimmunity and chromosomal karyotype analysis can determine the presence of chromosomal abnormalities. The measurement of serum FSH, LH, T and PRL is an important method for the examination of oligospermia and also helps to identify whether it is primary or secondary testicular failure. Second, the sperm is not liquefied to do the biochemical examination of semen: currently carried out more is acid phosphatase, citric acid, fructose, protein, trace elements, lactate dehydrogenase X, etc.. (1) Acid phosphatase: measured by β-glycerophosphate method. The normal value is 882±412 Brønsted units/ml. The enzyme is mainly from the prostate. It is related to the viability and metabolism of spermatozoa. Sperm-specific enzymes-lactate dehydrogenase X (L-DHX) and LDH isoenzyme have relative tissue specificity and are related to spermatogenic function. This enzyme is reduced in male infertility patients who take too much raw cottonseed oil. (2) Citric acid: measured by Furthherrmann reaction, the normal value is 56±2. 0mg/dl, mainly from the prostate, regulates the concentration of calcium ions in semen, affects the liquefaction of semen, has the role of prostatic acid phosphatase activator, thus affecting sperm vitality. When there is inflammation in the prostate, the citric acid content is significantly reduced. (3) Protein: Measured by the double shrinkage urine method. The protein in semen mainly comes from the seminal vesicles and prostate gland, which can promote sperm vitality and protect sperm from harmful effects of the environment. (4) Trace elements: have an important role in male reproduction and reproductive endocrine function. Normal semen zinc is 130±56μg/ml, copper:1. 85±0. 15μg/ml, iron: 0. 81±0. 04μg/ml. (5) Fructose determination: generally by resorcinol method, normal value is 256±104mg/dl. Fructose is mainly secreted by seminal vesicles, is the main source of sperm energy metabolism, and is related to sperm viability. Third, testicular ultrasound: the use of this examination can find testicular bulk lesions, testicular biopsy can provide a more solid basis for diagnosis and treatment. Daily health care Sperm liquefaction and zinc deficiency are greatly related. The lack of zinc should be supplemented in time, a single food supplement is not comprehensive and timely, which is why usually eat more zinc-containing food but also lack of zinc. The usual diet to supplement zinc, it is advisable to eat more coarse flour, tofu and other soybean products, beef, mutton, fish, lean meat, peanuts, sesame, dairy products and other foods. Foods rich in selenium include:seafood, mushrooms, eggs, garlic, ginkgo, etc. When the body is not deficient in zinc and there are no symptoms, more attention to diet will be enough. The experts pointed out that the male friends suffering from spermatozoa indefinition will seriously affect the fertility problem, the patient friends in addition to identify the cause of active treatment, the diet can also be properly adjusted to play the purpose of supplementary treatment. The actual spermatozoa are not only a good idea, but they are also a great way to get the most out of your life. Spermatozoa liquefaction is recommended to consume more tomatoes, watermelon, lamb leek and seafood containing shellfish. General methods (1) Thoroughly treat primary lesions such as prostatitis and seminal vesicle adenitis to restore their normal function. (2) Use saline containing 4% alpha amylase to rinse the vagina before sexual intercourse or inject 1 ml in the vagina after sexual intercourse. The enzyme can also be mixed with 50 mg of cocoa butter to make a 3 cm long plug and inserted into the vagina before intercourse. The discovery of this method was inspired by the observation that saliva has the ability to liquefy semen. α-amylase not only promotes the liquefaction of semen and affects glycogen-containing vaginal or cervical secretions, but also serves as a source of energy for sperm activity. Therefore, this method is widely used. (3) Adding normal human seminal plasma to semen to induce liquefaction. However, it is first necessary to make sure that this seminal plasma does not contain anti-sperm antibodies, is free of infection, and has been previously processed by high-speed centrifugation, removal of sediment and freeze-thawing 3 times. (4) The semen is ejected into a container with culture fluid and repeatedly aspirated with a syringe with an 18 or 19 gauge needle until the semen is thin, then centrifuged twice, washed, and finally the sperm is resuspended in a certain amount of culture fluid for artificial insemination. (5) If the semen is too viscous, the segmental ejaculation method can be used, leaving the first three ejaculations in the vagina, immediately withdrawing the penis and ejaculating the rest of the semen outside. Because the latter section of semen mainly contains seminal vesicle gland secretion, it is more viscous. Precautions 1. Take more exercise. Studies have shown that excessive obesity in men’s bodies can lead to an increase in temperature in the groin, which damages the growth of sperm and thus leads to infertility. Therefore, weight control within the standard range can improve the quality of sperm. 2, relax the mind. Excessive mental stress also has a negative impact on the growth of sperm, so men should properly relax themselves. 3, frequent medical checkups at clinics. Germ infections are also an important factor in male infertility, and you should visit your physician often to receive examinations related to chlamydia and prostate. 4, less to sauna, steam bath. The high temperature steam baths directly harm sperm and also inhibit sperm production. 5. Quit smoking and drinking. The data shows that smoking and drinking are the most important factors in the decline of sperm quantity and quality. 6, reduce the use of cosmetics. Research shows that cosmetics contain harmful substances such as phthalates, is the cause of male sperm count and fertility decline in the past few decades, “the culprit. The actual fact is that you can find a lot of people who are not able to get a good deal on a lot of things. 8, try to eat less greasy food: some patients with spermatozoa liquefaction generally have greater damp heat, more yellow urine, great smell, and also have symptoms such as foul-smelling stools, bitter mouth, and greasy tongue, etc. These patients should not eat too much greasy food in addition to spicy and stimulating food. The actual fact is that you can find a lot of people who are not able to get a good deal on a lot of things. The sperm is not liquefied, but it is a common clinical phenomenon and a common cause of male infertility. In addition to medication, it is necessary to pay attention to some details in life. It is important to pay attention to scientific diet. For poor semen liquefaction caused by some infectious factors, such as those belonging to seminal vesiculitis or prostatitis, patients often have some symptoms of urinary tract infection, with symptoms such as painful urination, frequent urination, urgent urination, and lowering of the abdomen. These manifestations, from the perspective of Chinese medicine, often belong to “yin deficiency and fire”, yin deficiency refers to kidney yin deficiency, while the fire is internal heat caused by false fire on the inflammation, fire heat decoction yin liquid, water dissipation, so the sticky end occurs. In this case, you should avoid a spicy and stimulating diet, such as chili peppers, wine, and big ingredients (pepper, fennel, wicker, pepper, etc., most of which are hot and should not be consumed), should be avoided. Eat less oily and greasy products. For some men with poor semen liquefaction, TCM identifies those with damp-heat injection, with yellowish red urine, big odor, foul-smelling stools, bitter mouth, greasy tongue, etc. In addition to not eating spicy food, they should not eat too much fatty food, and those with a taste for smoking and alcohol, it is best to quit temporarily, because excessive damp-heat is often an important factor in causing thick semen. In addition, Chinese medicine identifies some people with semen non-liquidity as phlegm and stagnation, body deficiency and heavy dampness, such as obesity, dizziness, weight, etc., and should not consume greasy food. It is very important to eat more vegetables and fruits appropriately. It is not advisable to abuse tonic medicine. When dampness and heat are relatively heavy, you should not abuse tonic medicine. Chinese medicine speaks of heat and dampness, are real evidence, only deficiency evidence can use tonic drugs, if regardless of the three or seven, the use of tonic drugs, often aggravate the condition. Not only will liquefaction not improve, but it will worsen. If you’re not in a position to use the remedy, you should do so under the guidance of a doctor. Influence harm Fertility influence If it fails to liquefy completely within 30 minutes after ejaculation, it is called delayed liquefaction, which has some influence on fertility; if it still does not liquefy for more than one hour, it is only called semen non-liquefaction, and sperm is trapped by semen, just like a person swimming in mud, and it is difficult to move an inch, which is one of the common causes of male infertility. The coagulation and liquefaction of semen is mainly regulated by the balance of liquefaction and coagulation factors secreted by the prostate and seminal vesicle glands. When there is a problem with the prostate gland, such as inflammation of the prostate or secretion dysfunction (low androgen levels, etc.), it can lead to semen not liquefying. Since those with abnormal semen liquefaction can be accompanied by infectious diseases of the reproductive tract such as prostatitis, anti-infection treatment along with drugs to improve the secretion function of the prostate is the fundamental way to improve semen non-liquefaction. For patients whose treatment with the above methods does not work, we can consider pre-treating the semen outside the body first, and then performing artificial insemination of the husband’s semen (AIH). The disease hazard Sperm non-liquefaction basically cannot make the woman pregnant. Sperm non-liquefaction mostly originates from prostate disease, when inflammation occurs in the prostate or seminal vesicle gland, due to the lack or destruction of the secretion of protein hydrolytic enzymes, resulting in the dysregulation of the enzyme system, making some patients’ semen not liquefy even after being placed for one hour, or incomplete liquefaction and too high viscosity, making the problem very serious. This is called semen non-liquefaction and is a pathological phenomenon in which the sperm cannot move and can cause infertility. Therefore, diseases of the seminal vesicles and prostate gland are important causes of non-liquefaction. Prostate dysfunction is present in 90% of patients with semen non-liquefaction, the most common cause of which is prostatitis, resulting in decreased secretion of lysozyme and non-liquefaction. In addition, diseases such as varicocele can cause endocrine dysfunction of the testes and reduced secretion of testosterone, leading to a decrease in the secretion function of the accessory gonads, which can also lead to the formation of semen non-liquefaction, thus affecting the vitality of sperm. Normal sperm non-liquefaction is conducive to stay in the female vagina. The newly ejaculated semen is initially solidified, at which time the sperm is inactive, and then the solidified semen will be liquefied in a short time before the sperm starts to move, and under normal circumstances, this process will not exceed one hour. If it is longer than that, the semen is not liquefied and will lead to prolonged restriction of sperm activity resulting in the inability to conceive.