Osteomalacia is a rare and harmless osteosclerotic disease, also known as diffuse dense bone disease, familial diffuse osteosclerosis, and punctate bone. The clinical differential diagnosis is as follows: 1. Osteogenic bone metastases: patients with significant clinical symptoms, primary lesions, commonly in the spine, proximal end of long bones, and asymmetrical distribution of metastases. 2, bone wax tear-like disease: the lesion occurs in the long bone stem and epiphysis within the bone and outside the bone cortex, irregular stripes of osteosclerosis, often invade the unilateral limb. 3, bone decompression disease: the lesion is usually found at the ends of long tubular bones, but rarely occurs in the short bones of the limbs, with striated sclerotic spots and cystic translucent areas. Patients have a history of diving operations. Although osteomalacia is a harmless disease without inflammation, necrosis and pathological fracture, some data reported a trend of osteosarcoma associated with osteomalacia, which should be given high priority.