Many people have questions about whether gallbladder stones require surgery, when to operate, and what is the better procedure. In principle, if the diagnosis of gallbladder stones is clear, surgery should be performed to remove the gallbladder to prevent acute cholecystitis or other serious complications caused by gallbladder stones, such as common bile duct stones, acute cholangitis and acute pancreatitis. In general, asymptomatic gallbladder stones can be removed without immediate cholecystectomy, but the surgery should be elective. However, cholecystectomy should be done as soon as possible if one of the following conditions exists (1), recurrent symptoms or acute cholecystitis; (2), large stones (2-3cm), large number, especially those with long history (more than 10 years), risk of gallbladder cancer; (3), older (>60 years), with hypertension, cardiac insufficiency, diabetes mellitus, etc. —– because once the complications of gallbladder stones occur, the morbidity and mortality rate is extremely high; (4), gallbladder full of stones or porcelain gallbladder, the gallbladder has no function, and easy to complicate gallbladder cancer, early removal is appropriate; (5), remote mountainous areas, poor medical conditions, should be early preventive removal. —— Once serious complications such as acute cholecystitis or acute pancreatitis occur, they are often incurred due to untimely treatment. Laparoscopic cholecystectomy (commonly known as “eyelet”) is currently the classic procedure for the treatment of gallbladder disease and is the first choice. However, there are some patients who are not suitable for “eye surgery” and need open cholecystectomy, mainly in the following two cases: (1) suspected or confirmed malignant gallbladder lesions; (2) history of complex upper abdominal surgery and serious intra-abdominal adhesions.