Old Zhang recently always can not play the spirit, feel that nothing is meaningful. Less talk, always sitting and worrying, either lying down. Doing something feel tired. The family advised him to go out and take a break, and he could hardly summon up the courage to go and see the chess game he usually liked, but he felt that he could not keep up with others’ thoughts, so he felt uncomfortable, and the usual fun of watching chess was gone. Sometimes I couldn’t help but shed tears, and I felt that I was having a particularly hard time, as if I had fallen into an abyss. At night, I seemed to be in a better mood, and I could talk to my family. I looked forward to going to sleep, but I woke up in the early morning before dawn, waiting for another day to pass like a year. Can not eat, constipation, chest tightness, a month lost more than ten pounds. Went to the hospital for a checkup, did not say what disease, he felt he might have a terminal illness that could not be cured, the family and doctors did not tell the truth to themselves. Old Zhang after the hospital examination is suffering from depression. So what exactly are the clinical manifestations of depression? The symptoms of depression are mainly in the following six areas: 1. If the patient was a person with a wide range of interests, this is often very obvious. For those who have a rigid and monotonous life, this symptom may be difficult to determine. However, it is possible to find out by talking to the patient about the feelings of daily life or routines. When a housewife suffers from depression, she often does not experience any pleasure in running the household or bringing up the children, and even feels a burden, which is a completely different experience from the one before the disease. 2. A sense of hopelessness. Every normal person will have hope and expectation for the future, and even have a strong desire or longing for certain things. Depressed patients lose these. For them, the future is gray and there is no light in sight. Severe cases feel despair, everything is so bad for the individual that it is irreparable, and they even think that the future of human beings is also hopeless. 3.Sense of helplessness. The patient feels that he is in an isolated situation, like falling in the middle of the ocean or at the bottom of the abyss, unable to extricate himself, and no one can save him or help him. Some patients say to the doctor that he can appreciate the doctor’s good intentions and valuable efforts for him, but it does not help, which makes him very ashamed and guilty. 4. Loss of motivation and incentive. The patient feels no energy, as if the fountain of life has dried up. He does not want to do anything, there is no source of motivation, even if he can barely do something, he feels overwhelmed and very difficult, in fact, nothing can be done. The patient sometimes thought that he had to pull himself together, but he could not do so. The patient painfully feels that he seems to have broken down from the “root”: the patient complains that his memory is bad, he cannot remember anything, he has completely lost the ability to think and cannot even think”, his mind is empty. 5. Loss of self-esteem and self-confidence, and a significant decline in self-evaluation. Patients believe that they do not know anything, can not do anything, will not do anything, is simply a total waste. Severe cases have the concept of self-criminality, looking back on the past to feel that they are worthless and sinful. 6. Feeling that life is meaningless. This is not just a feeling that a specific activity is meaningless, but everything in life is meaningless, life itself is meaningless. Patients often have thoughts of death, and even have plans and actions to commit suicide. All of these symptoms are declining, diminishing, absent, or lost, and are therefore often summarized by a sense of loss. But loss has a much broader meaning than the above symptoms. Life is always a gain and a loss, and when one feels that the gain is equal to or even greater than the loss, one has a sense of loss. Married and gaining love but losing freedom. Feel the love of your husband but lose the love of your parents. This can all lead to a sense of disappointment. But obviously this is not all pathological. Perhaps the depressive symptoms are that severe and deep sense of loss.