What are the causes of osteomalacia?

  Osteomalacia is a rare and harmless osteosclerotic disease, also known as diffuse dense bone disease, familial diffuse osteosclerosis, and punctate bone. It was first reported by Alber-shonberg in 1915. The incidence has been estimated to be less than 1 in 10 million of the population.  It is now thought to be about 1 in 1 million, and as more cases are detected over time with increased imaging, the incidence will be higher than these figures. The cause of the disease is unknown to date, it has been reported from fetal to under 69 years of age, can have a family history, is hereditary, and has a higher incidence in males than females. The disease is mostly without clinical symptoms and laboratory tests are not positive. It is occasionally detected on radiographic examination. The following is the specific pathogenesis of osteomalacia.  Bone speckle disease can be divided into a generalized form and a limited form. Because the speckled bone is mainly located in the epiphysis and epiphysis where the cartilaginous endochondral bone is actively growing, it has been reported in the literature to be associated with congenital disorders of osteogenesis of cartilaginous bone. The disease is characterized by the appearance of multiple small, dense, grayish-white, round or oval bony masses confined within cancellous bone, rarely in the tubular bone cadre, and not associated with the bone cortex or epiphysis. Microscopically, speckled osteosclerosis is observed as tightly arranged bone platelets of varying thickness, mostly parallel to the long axis of the bone, with a few arranged diagonally. It has been reported that there is a tendency for the bone patches to decrease gradually with age.